Shah, Dhaval K.,

Modeling of antibody-drug conjugate pharmacokinetics [electronic resource] / Dhaval K. Shah. - London : Henry Stewart Talks, 2019. - 1 online resource (1 streaming video file (49 min.) : color, sound). - Periodic reports : advances in clinical interventions and research platforms, 2056-452X . - Henry Stewart talks. Biomedical & life sciences collection. Periodic reports. .

Animated audio-visual presentation with synchronized narration. Title from title frames.

Contents: Antibody drug conjugates (ADCs) and their uses -- Different ways to measure ADCs in the cell -- Typical ADC PK in cells -- Modeling the cellular PK of ADCs -- Modeling the tumor PK of ADCs -- 7 steps -- Modeling whole-body PK of ADCs -- Combining PK and PD models -- Kadcyla case study.

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Mode of access: World Wide Web.

4963 Henry Stewart Talks


Antibody-drug conjugates.
Antineoplastic agents.
Drug development.
Antibodies, Monoclonal--pharmacokinetics.
Antineoplastic Agents--therapeutic use.
Computer Simulation.
Drug Design.
Drug Discovery--methods.
Immunoconjugates--pharmacokinetics.
Immunoconjugates--pharmacology.
Maytansine.
Models, Biological.
Trastuzumab.
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