000			01825ngm a2200313 a 4500
001			HST2548_1_2
003			UkLoHST
006			m c
007			cr|cna|||a||||
007			vz|czazum
008			100409s2009 enk|||||||||||s|||v|eng d
028	5	0	_a2548 _bHenry Stewart Talks
035			_a(UkLoHST)1533
040			_aUkLoHST _beng _cUkLoHST
100	1		_aGagneux, Sébastian. _4spk
245	1	0	_aFitness and compensation _h[electronic resource] / _cSébastian Gagneux.
260			_aLondon : _bHenry Stewart Talks, _c2009.
300			_a1 online resource (1 streaming video file (34 min.) : _bcolor, sound).
490	1		_aAntibiotic resistance : from genes to global prevalence, _x2056-452X
500			_aAnimated audio-visual presentation with synchronized narration.
500			_aTitle from title frames.
505	0		_aContents: Concept of Darwinian fitness -- Understanding the fitness impact of drug resistance -- Mathematical models -- Reversal of drug resistance in bacteria -- How to measure fitness -- The molecular epidemiology approach -- Effect of drug resistance mutations -- Environment effects on fitness measurements -- Effect of strain genetic background -- Pre-adapted strain "families" -- Biogeography of M. tuberculosis -- Compensatory evolution -- Experimental evidence -- Compensation prevents reversion to drug sensitivity -- Types of compensatory mutations -- Questions for future research -- Comparative genomics.
506			_aAccess restricted to subscribers.
538			_aMode of access: World Wide Web.
650		2	_aDrug Resistance, Microbial.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pAntibiotic resistance : from genes to global prevalence.
856	4	0	_uhttps://hstalks.com/bs/1533/
856	4	2	_uhttps://hstalks.com/bs/p/442/ _3Series
999			_c78619 _d78619