000			02116ngm a2200325 a 4500
001			HST2026_1_3
003			UkLoHST
006			m c
007			cr|cna|||a||||
007			vz|czazum
008			080121s2009 enk|||||||||||s|||v|eng d
028	5	0	_a2026 _bHenry Stewart Talks
035			_a(UkLoHST)1281
035			_a(UkLU-K)001103486
040			_aUkLU-K _beng _cUkLU-K
100	1		_aBeutler, Bruce. _4spk
245	1	0	_aInnate immune sensing and response _h[electronic resource] / _cBruce Beutler.
260			_aLondon : _bHenry Stewart Talks, _c2009.
300			_a1 online resource (1 streaming video file (62 min.) : _bcolor, sound).
490	1		_aInnate immunity : host recognition and response in health and disease, _x2056-452X
500			_aAnimated audio-visual presentation with synchronized narration.
500			_aTitle from title frames.
505	0		_aContents: Sensing infection is essential to the initiation of an immune response -- The innate immune system senses signature molecules made by microbes using a conserved set of germline-encoded receptors -- This receptor family (the Toll-like receptors) was first understood when a mutation that abolished lipopolysaccharide (LPS) sensing was positionally cloned in mice -- In Drosophila a homologous receptor is also used to detect infection, and still another receptor activates a pathway evocative of the tumor necrosis factor (TNF) pathway in mammals -- Further work in mammals has depended upon gene targeting and also forward genetic work, which has revealed many of the components of the TLR signaling apparatus -- Forward genetics has also allowed us to see how many genes (and what kinds of genes) are important for resisting an infection in vivo.
506			_aAccess restricted to subscribers.
538			_aMode of access: World Wide Web.
650		2	_aImmunity, Innate.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pInnate immunity : host recognition and response in health and disease.
856	4	0	_uhttps://hstalks.com/bs/1281/
856	4	2	_uhttps://hstalks.com/bs/p/437/ _3Series
999			_c78522 _d78522