000 02264ngm a2200337 a 4500
001 HST1911_1_2
003 UkLoHST
006 m c
007 cr|cna|||a||||
007 vz|czazum
008 080121s2008 enk|||||||||||s|||v|eng d
028 5 0 _a1911
_bHenry Stewart Talks
035 _a(UkLoHST)952
035 _a(UkLU-K)AC000395881
040 _aUkLU-K
_beng
_cUkLU-K
100 1 _aManson, Jean.
_4spk
245 1 0 _aPredicting TSE transmission
_h[electronic resource] /
_cJean Manson.
260 _aLondon :
_bHenry Stewart Talks,
_c2008.
300 _a1 online resource (1 streaming video file (41 min.) :
_bcolor, sound).
490 1 _aPrions and amyloids : self-propagating protein structures in mammals, yeast and fungi,
_x2056-452X
500 _aAnimated audio-visual presentation with synchronized narration.
500 _aTitle from title frames.
505 0 _aContents: The TSEs continue to pose a problem to animal and human health -- The vCJD epidemic appears to be in decline but new risks of human to human transmission are now apparent -- Chronic wasting disease is a major problem currently in the US although its presence has not yet been detected in Europe -- Predicting and preventing transmission of disease requires an understanding of the routes of transmission within and between animals and the host factors which determine susceptibility -- We have studied natural disease and both in vivo and in vitro model systems to unravel the basic mechanisms of disease -- PrP protein has a central role in the outcome disease and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent -- Precisely how host PrP influences the outcome of disease has not been established -- Both mutations and glycosylation can profoundly influence transmission both within and between species.
506 _aAccess restricted to subscribers.
538 _aMode of access: World Wide Web.
650 2 _aAmyloid.
650 2 _aPrions.
830 0 _aHenry Stewart talks.
_pBiomedical & life sciences collection.
_pPrions and amyloids : self-propagating protein structures in mammals, yeast and fungi.
856 4 0 _uhttps://hstalks.com/bs/952/
856 4 2 _uhttps://hstalks.com/bs/p/282/
_3Series
999 _c78404
_d78404