000			03069ngm a2200409 a 4500
001			HST1926_1_2
003			UkLoHST
006			m c
007			cr|cna|||a||||
007			vz|czazum
008			080121s2008 enk|||||||||||s|||v|eng d
028	5	0	_a1926 _bHenry Stewart Talks
035			_a(UkLoHST)762
035			_a(UkLU-K)AC000392170
040			_aUkLU-K _beng _cUkLU-K
100	1		_aSmith, Quentin R. _4spk
245	1	0	_aCNS drug design _h[electronic resource] / _cQuentin R. Smith.
260			_aLondon : _bHenry Stewart Talks, _c2008.
300			_a1 online resource (1 streaming video file (46 min.) : _bcolor, sound).
490	1		_aSmall molecule drug discovery, _x2056-452X
490	1		_aThe blood-brain barrier : understanding the regulatory gatekeeper between brain and body, _x2056-452X
500			_aAnimated audio-visual presentation with synchronized narration.
500			_aTitle from title frames.
505	0		_aContents: Central nervous system diseases -- Drug market for CNS disorders -- Traditional CNS drug targets -- Novel CNS drug targets -- Multiple obstacles for drug delivery to CNS -- Pathways for drug exchange within the CNS -- The structure of brain capillaries impedes uptake -- Measures of drug uptake and distribution in brain -- BBB permeability and solute lipid solubility -- Tissues capillary PS and 95 per cent equilibration time -- Cerebral blood flow affects drug uptake and Kin -- Initial uptake vs. steady-state distribution -- Plasma protein binding and brain drug uptake -- Brain capillary drug transporters -- Transporters and drug distribution across BBB -- "Enzymatic" blood-brain barrier -- Relation between bound and free drug -- Free drug distribution ratio at steady state -- BBB changes in pathology and disease -- Drug-like properties to cross the BBB -- Early findings in BBB drug uptake -- Measures of lipophilicity -- Passive permeability across lipid membranes -- Drug ionization -- Influence of pH on neutral fraction -- Lipinski "rule of five" -- Impact of hydrogen bonds and alkyl groups -- Positive CNS drugs -- Poor CNS drug -- in vitro measures -- In vivo measures -- Methods to improve brain uptake -- Simple rules for efflux transporters -- % drug distribution to brain -- Biologic compounds -- Brain pharmacokinetics.
506			_aAccess restricted to subscribers.
538			_aMode of access: World Wide Web.
650		2	_aBlood-Brain Barrier.
650		2	_aBrain.
650		2	_aCentral Nervous System Diseases _xdrug therapy.
650		2	_aDrug Design.
650		2	_aMolecular Targeted Therapy.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pBlood-brain barrier : understanding the regulatory gatekeeper between brain and body.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pSmall molecule drug discovery.
856	4	0	_uhttps://hstalks.com/bs/762/
856	4	2	_uhttps://hstalks.com/bs/p/277/ _3Series (Blood-brain barrier)
856	4	2	_uhttps://hstalks.com/bs/p/739/ _3Series (Small molecule drug discovery)
999			_c78331 _d78331