000			02942ngm a2200409 a 4500
001			HST1026_1_2
003			UkLoHST
006			m c
007			cr|cna|||a||||
007			vz|czazum
008			080121s2007 enk|||||||||||s|||v|eng d
028	5	0	_a1026 _bHenry Stewart Talks
035			_a(UkLoHST)112
035			_a(UkLU-K)AC000390080
040			_aUkLU-K _beng _cUkLU-K
100	1		_aMartienssen, Robert A. _4spk
245	1	0	_aRNAi and heterochromatin in plants and fission yeast _h[electronic resource] / _cRobert Martienssen.
260			_aLondon : _bHenry Stewart Talks, _c2007.
300			_a1 online resource (1 streaming video file (41 min.) : _bcolor, sound).
490	1		_aEpigenetics : concepts, theories, paradigms and mechanisms, _x2056-452X
490	1		_aRNA interference : principles and applications, _x2056-452X
500			_aAnimated audio-visual presentation with synchronized narration.
500			_aTitle from title frames.
505	0		_aContents: Heterochromatin is composed of transposable elements (TEs) and related repeats -- heterochromatic gene silencing and TE-mediated silencing are related and may be important in large genomes -- tiling microarrays can be used to examine heterochromatic transcripts as well as DNA and histone modification -- small interfering RNA (siRNA) corresponds to transposons and repeats -- in plants TE siRNA depend on DNA methyltransferase MET1 and the SWI/SNF ATPase DDM1 which silence TEs via DNA and histone H3 lysine-9 (H3K9) methylation -- in fission yeast and plants centromeric repeats are transcribed on one strand but rapidly turned over by RNA interference (RNAi) -- RNAi of centromeric transcripts is required for transcriptional silencing of reporter genes -- RNA polymerase II, the Argonaute (RITS) and RNA dependent RNA polymerase (RDRC) complexes are associated with heterochromatin and required for silencing -- H3K9me2 depends on RNAi and on the Rik1-Clr4 complex -- Clr4 is the histone H3K9 dimethyltransferase -- Rik1 resembles both DNA and RNA binding proteins and is required for RNAi along with Clr4 -- LTR retrotransposon silencing depends on histone deacetylation and silences pericentromeric repeats in Arabidopsis in addition to RNAi.
506			_aAccess restricted to subscribers.
538			_aMode of access: World Wide Web.
650		2	_aEpigenesis, Genetic.
650		2	_aHeterochromatin.
650		2	_aPlants.
650		2	_aRNA Interference.
650		2	_aSchizosaccharomyces.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pEpigenetics : concepts, theories, paradigms and mechanisms.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pRNA interference : principles and applications.
856	4	0	_uhttps://hstalks.com/bs/112/
856	4	2	_uhttps://hstalks.com/bs/p/18/ _3Series (Epigenetics)
856	4	2	_uhttps://hstalks.com/bs/p/37/ _3Series (RNA interference)
999			_c77767 _d77767