000			02098ngm a2200337 a 4500
001			HST1021_1_2
003			UkLoHST
006			m c
007			cr|cna|||a||||
007			vz|czazum
008			080121s2007 enk|||||||||||s|||v|eng d
028	5	0	_a1021 _bHenry Stewart Talks
035			_a(UkLoHST)107
035			_a(UkLU-K)AC000390011
040			_aUkLU-K _beng _cUkLU-K
100	1		_aLyon, Mary F. _4spk
245	1	2	_aA historical perspective on ideas on X-chromosome inactivation _h[electronic resource] / _cMary Lyon.
260			_aLondon : _bHenry Stewart Talks, _c2007.
300			_a1 online resource (1 streaming video file (34 min.) : _bcolor, sound).
490	1		_aEpigenetics : concepts, theories, paradigms and mechanisms, _x2056-452X
500			_aAnimated audio-visual presentation with synchronized narration.
500			_aTitle from title frames.
505	0		_aContents: The phenomenon of X-chromosome inactivation in female mammals -- X-chromosome inactivation as a dosage compensation mechanism for equalising the dosage of X-linked gene products in XY males and XX females in somatic cells -- inactivity of either the maternal or paternal X-chromosome in different cells in eutherian mammals -- preferential inactivation of paternal X in the placenta of mice and in all cells of marsupials -- initiation of the process from an X-inactivation centre -- discovery of the key gene, Xist -- the concept of initiation and maintenance of X-inactivation as separate processes -- histone modifications and methylation of CpG islands as maintenance mechanisms -- inactivation in autosomal and X-chromosomal DNA -- LINE1s as booster elements on the X-chromosome.
506			_aAccess restricted to subscribers.
538			_aMode of access: World Wide Web.
650		2	_aEpigenesis, Genetic.
650		2	_aX Chromosome Inactivation.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pEpigenetics : concepts, theories, paradigms and mechanisms.
856	4	0	_uhttps://hstalks.com/bs/107/
856	4	2	_uhttps://hstalks.com/bs/p/18/ _3Series
999			_c77762 _d77762