| 000 | 02279ngm a2200337 a 4500 | ||
|---|---|---|---|
| 001 | HST2379_1_2 | ||
| 003 | UkLoHST | ||
| 006 | m c | ||
| 007 | cr|cna|||a|||| | ||
| 007 | vz|czazum | ||
| 008 | 080121s2009 enk|||||||||||s|||v|eng d | ||
| 028 | 5 | 0 |
_a2379 _bHenry Stewart Talks |
| 035 | _a(UkLoHST)1271 | ||
| 035 | _a(UkLU-K)001155637 | ||
| 040 |
_aUkLU-K _beng _cUkLU-K |
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| 100 | 1 |
_aLane, David, _d1952- _4spk |
|
| 245 | 1 | 0 |
_aDrug discovery and target validation in the p53 pathway _h[electronic resource] / _cDavid Lane. |
| 260 |
_aLondon : _bHenry Stewart Talks, _c2009. |
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| 300 |
_a1 online resource (1 streaming video file (40 min.) : _bcolor, sound). |
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| 490 | 1 |
_aThe cell division cycle : controlling when and where cells divide and differentiate, _x2056-452X |
|
| 500 | _aAnimated audio-visual presentation with synchonized narration. | ||
| 500 | _aTitle from title frames. | ||
| 505 | 0 | _aContents: Controlling cancer -- p53 discovery -- Oncoproteins -- SV40, Adeno and HPV -- The p53 protein -- Incidence of genetic changes in p53 in human cancers -- What does p53 do? -- The p53 pathway is blocked in many tumor cells -- p53 and HDM2 are connected by a negative feedback loop -- Mdm2 controls p53 -- Evidence for the fine regulation of the p53 response -- How does p53 cause advanced aging? -- Therapy approaches -- Gene therapy -- Activating p53 -- Targets for p53 activation -- Small peptides block p53/HDM interaction and activate p53 -- Peptide minimization and optimization -- Nutlin 3 specificity -- Thousands of compounds can be tested for their ability to activate p53-dependent transcription -- CYC202: a cdk inhibitor in clinical trial that is a non genotoxic activator of the p53 response -- CDK inhibition -- Regulation of p53 by ubiquitin like proteins -- Stress stimuli that control the activity of p53 -- New isoforms of p53. | |
| 506 | _aAccess restricted to subscribers. | ||
| 538 | _aMode of access: World Wide Web. | ||
| 650 | 2 | _aCell Cycle. | |
| 650 | 2 | _aGenes, cdc. | |
| 830 | 0 |
_aHenry Stewart talks. _pBiomedical & life sciences collection. _pCell division cycle : controlling when and where cells divide and differentiate. |
|
| 856 | 4 | 0 | _uhttps://hstalks.com/bs/1271/ |
| 856 | 4 | 2 |
_uhttps://hstalks.com/bs/p/381/ _3Series |
| 999 |
_c77744 _d77744 |
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