000			02143ngm a2200325 a 4500
001			HST2713_1_2
003			UkLoHST
006			m c
007			cr|cna|||a||||
007			vz|czazum
008			110112s2010 enk|||||||||||s|||v|eng d
028	5	0	_a2713 _bHenry Stewart Talks
035			_a(UkLoHST)1880
040			_aUkLoHST _beng _cUkLoHST
100	1		_aCantley, Lewis. _4spk
245	1	0	_aRole of the PI 3-kinase signaling pathway in cell regulation and human disease _h[electronic resource] / _cLewis Cantley.
260			_aLondon : _bHenry Stewart Talks, _c2010.
300			_a1 online resource (1 streaming video file (32 min.) : _bcolor, sound).
490	1		_aProtein phosphorylation, _x2056-452X
500			_aAnimated audio-visual presentation with synchronized narration.
500			_aTitle from title frames.
505	0		_aContents: Phosphoinositide 3-kinase (PI3K) signaling -- Class Ia PI3K's and the mediation of growth factor signaling -- The receptor tyrosine kinase signaling pathway -- Loss-of-function mutations in tumor suppressors -- Sporadic mutations -- Drug targets -- Regulation of metabolism by PI3K AKT signaling -- Targets of the drug NVP BEZ235 -- Generation of mice with mutant PI3K p110a -- How lung adenocarcinoma requires mutant PI3K -- HIF-1alpha -- Visualizing lung tumors using FDG PET -- How mTOR inhibition does not reduce tumor volume -- Will a PI3K inhibitor kill K-Ras driven tumors? -- How AKT inhibition does not affect tumor size or activity -- Effects of BEZ235 in K-Ras mutant tumors -- How BEZ235 specifically kills PI3K driven tumors -- The drug ARRY 886 -- How PI3K with MEK inhibitors eradicates K-Ras tumors -- Blocking the PI3K and MAP Kinase pathways -- Inhibition of S6 kinase in K-Ras tumors.
506			_aAccess restricted to subscribers.
538			_aMode of access: World Wide Web.
650		2	_aPhosphatidylinositol 3-Kinases.
650		2	_aSignal Transduction.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pProtein phosphorylation.
856	4	0	_uhttps://hstalks.com/bs/1880/
856	4	2	_uhttps://hstalks.com/bs/p/531/ _3Series
999			_c77619 _d77619