000			01864ngm a2200373 a 4500
001			HST2684_1_2
003			UkLoHST
006			m c
007			cr|cna|||a||||
007			vz|czazum
008			110112s2010 enk|||||||||||s|||v|eng d
028	5	0	_a2684 _bHenry Stewart Talks
035			_a(UkLoHST)1896
040			_aUkLoHST _beng _cUkLoHST
100	1		_aMarais, Richard, _u(The Institute of Cancer Research, UK) _4spk
245	1	0	_aRAS and RAF signaling in melanoma _h[electronic resource] : _bbiology and therapies / _cRichard Marais.
246	3		_aRAS and RAF signalling in melanoma
260			_aLondon : _bHenry Stewart Talks, _c2010.
300			_a1 online resource (1 streaming video file (37 min.) : _bcolor, sound).
490	1		_aProtein phosphorylation, _x2056-452X
500			_aAnimated audio-visual presentation with synchronized narration.
500			_aTitle from title frames.
505	0		_aContents: Melanoma -- BRAF and RAS mutated in approximately 70% of cases -- Mouse models of melanoma -- Oncogenic BRAF can be a founder mutation in melanoma -- Mouse models replicate human disease -- BRAF inhibitors induce paradoxical activation of CRAF and drive pathway activation -- Kinase-dead BRAF mimics this and potentiates RAS ooncogenesis -- BRAF inhibitors induce excellent responses in patients, but may induce mechanism-based side effects through CRAF.
506			_aAccess restricted to subscribers.
538			_aMode of access: World Wide Web.
650		2	_aGenes, ras.
650		2	_aMelanoma _xtherapy.
650		2	_aNeoplasm Proteins.
650		2	_aProto-Oncogene Proteins B-raf.
650		2	_aSignal Transduction.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pProtein phosphorylation.
856	4	0	_uhttps://hstalks.com/bs/1896/
856	4	2	_uhttps://hstalks.com/bs/p/531/ _3Series
999			_c77615 _d77615