000			02098ngm a2200373 a 4500
001			HST2974_1_2
003			UkLoHST
006			m c
007			cr|cna|||a||||
007			vz|czazum
008			111014s2011 enk|||||||||||s|||v|eng d
028	5	0	_a2974 _bHenry Stewart Talks
035			_a(UkLoHST)2072
040			_aUkLoHST _beng _cUkLoHST
100	1		_aNeyts, Johan, _u(Rega Institute for Medical Research, K.U.Leuven, Belgium) _4spk
245	1	0	_aTowards the development of potent therapy against the Hepatitis C virus _h[electronic resource] / _cJohan Neyts.
260			_aLondon : _bHenry Stewart Talks, _c2011.
300			_a1 online resource (1 streaming video file (50 min.) : _bcolor, sound).
490	1		_aAntivirals : latest developments and future progress, _x2056-452X
500			_aAnimated audio-visual presentation with synchronized narration.
500			_aTitle from title frames.
505	0		_aContents: The HCV genome and replication cycle -- Interferon development -- Ribavirin -- Antiviral and GTP depletion correlation -- Selective inhibitors of HCV replication -- The NS2 cysteine and the NS3 serine proteases -- Protease inhibitors -- The NS3 helicase as an antiviral target -- NS4A/NS3, NS4B and NS5A as antiviral targets -- The NS5B RNA dependent RNA polymerase -- Nucleoside and non-nucleoside HCV inhibitors -- Double and triple combination therapies -- Debio-025 -- Resistance to HCV inhibitors -- D320E peptide mutation effect -- Role of NS5A or NS5B in resistance -- Wild type and CypA knock down studies -- Cis-trans isomerase activity of cyclophilins.
506			_aAccess restricted to subscribers.
538			_aMode of access: World Wide Web.
650		0	_aAntiviral agents.
650		0	_aHepatitis C virus.
650		0	_aHepatitis C _xTreatment.
650		2	_aAntiviral Agents.
650		2	_aHepacivirus.
650		2	_aHepatitis C _xdrug therapy.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pAntivirals.
856	4	0	_uhttps://hstalks.com/bs/2072/
856	4	2	_uhttps://hstalks.com/bs/p/613/ _3Series
999			_c77497 _d77497