000			02525ngm a2200373 a 4500
001			HST3184_1_2
003			UkLoHST
006			m c
007			cr|cna|||a||||
007			vz|czazum
008			120417s2012 enk|||||||||||s|||v|eng d
028	5	0	_a3184 _bHenry Stewart Talks
035			_a(UkLoHST)2216
040			_aUkLoHST _beng _cUkLoHST
100	1		_aBabu, M. Madan, _u(University of Cambridge, UK) _4spk
245	1	0	_aIntrinsically unstructured proteins _h[electronic resource] : _bregulation and disease / _cM. Madan Babu.
260			_aLondon : _bHenry Stewart Talks, _c2012.
300			_a1 online resource (1 streaming video file (36 min.) : _bcolor, sound).
490	1		_aProtein homeostasis : folding proteins and maintaining the protein-protein interaction networks, _x2056-452X
500			_aAnimated audio-visual presentation with synchronized narration.
500			_aTitle from title frames.
505	0		_aContents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation.
506			_aAccess restricted to subscribers.
538			_aMode of access: World Wide Web.
650		0	_aGenetic regulation.
650		0	_aProtein folding.
650		2	_aGene Expression Regulation.
650		2	_aProtein Conformation.
650		2	_aProtein Folding.
650		2	_aTranscription Factors _xgenetics.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pProtein homeostasis.
856	4	0	_uhttps://hstalks.com/bs/2216/
856	4	2	_uhttps://hstalks.com/bs/p/641/ _3Series
999			_c77414 _d77414