000			02729ngm a2200457 a 4500
001			HST3437
003			UkLoHST
006			m c
007			cr|cna|||a||||
007			vz|czazum
008			140422s2014 enk|||||||||||s|||v|eng d
028	5	0	_a3437 _bHenry Stewart Talks
035			_a(UkLoHST)2721
040			_aUkLoHST _beng _cUkLoHST
100	1		_aSaunders, Norman, _d1938- _4spk
245	1	0	_aBarrier mechanisms in the developing brain _h[electronic resource] : _bprotection or vulnerability? / _cNorman Saunders.
260			_aLondon : _bHenry Stewart Talks, _c2014.
300			_a1 online resource (1 streaming video file (57 min.) : _bcolor, sound).
490	1		_aThe blood-brain barrier : understanding the regulatory gatekeeper between brain and body, _x2056-452X
500			_aAnimated audio-visual presentation with synchronized narration.
500			_aTitle from title frames.
505	0		_aContents: The brain develops within a well-defined internal environment -- The properties of this internal environment are determined by transporters in the cellular interfaces between the blood, brain and cerebrospinal fluid -- The transporters are effective because the intercellular spaces between the cells in the interfaces are sealed by tight junctions -- The transporters are both influx and efflux and many are active very early in brain development -- Although brain barrier mechanisms are present very early in development they are vulnerable to pathological conditions e.g. inflammation, which may result in barrier dysfunction and damage to the fragile developing brain -- These mechanisms thus provide protection and a stable internal environment, but some may render the developing brain more vulnerable e. g. inward transport of toxins such as mercury via a normal amino acid transporter.
506			_aAccess restricted to subscribers.
538			_aMode of access: World Wide Web.
650		0	_aBiological transport.
650		0	_aBlood-brain barrier.
650		0	_aBrain _xGrowth.
650		2	_aBlood-Brain Barrier _xcytology.
650		2	_aBlood-Brain Barrier _xembryology.
650		2	_aBlood-Brain Barrier _xgrowth & development.
650		2	_aBlood-Brain Barrier _xmetabolism.
650		2	_aBrain _xembryology.
650		2	_aBrain _xgrowth & development.
650		2	_aCapillary Permeability.
650		2	_aCarrier Proteins.
650		2	_aIntercellular Junctions _xmetabolism.
650		2	_aMaternal Exposure.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pBlood-brain barrier : understanding the regulatory gatekeeper between brain and body.
856	4	0	_uhttps://hstalks.com/bs/2721/
856	4	2	_uhttps://hstalks.com/bs/p/277/ _3Series
999			_c77113 _d77113