000			02837ngm a2200517 a 4500
001			HST3594
003			UkLoHST
006			m c
007			cr|cna|||a||||
007			vz|czazum
008			140422s2014 enk|||||||||||s|||v|eng d
028	5	0	_a3594 _bHenry Stewart Talks
035			_a(UkLoHST)2729
040			_aUkLoHST _beng _cUkLoHST
100	1		_aKlein, William L., _u(Northwestern University, USA) _4spk
245	1	0	_aTargeting Aß oligomers _h[electronic resource] : _ba molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease / _cWilliam L. Klein.
246	3		_aAmyloid beta oligomers : pathogenic ligands that attack dendritic spines
246	3		_aAß oligomers : pathogenic ligands that attack dendritic spines
246	3		_aTargeting AB oligomers
246	3		_aTargeting amyloid beta oligomers
260			_aLondon : _bHenry Stewart Talks, _c2014.
300			_a1 online resource (1 streaming video file (68 min.) : _bcolor, sound).
490	1		_aDrug discovery and development in the neurosciences, _x2056-452X
500			_aAnimated audio-visual presentation with synchronized narration.
500			_aTitle from title frames.
505	0		_aContents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.
506			_aAccess restricted to subscribers.
538			_aMode of access: World Wide Web.
650		0	_aAlzheimer's disease _xChemotherapy.
650		0	_aAlzheimer's disease _xDiagnosis.
650		0	_aAlzheimer's disease _xPathogenesis.
650		0	_aAmyloid beta-protein.
650		0	_aNervous system _xDegeneration.
650		2	_aAlzheimer Disease _xdrug therapy.
650		2	_aAlzheimer Disease _xetiology.
650		2	_aAlzheimer Disease _xmetabolism.
650		2	_aAlzheimer Disease _xpathology.
650		2	_aAmyloid beta-Peptides _xmetabolism.
650		2	_aBrain _xmetabolism.
650		2	_aNeurodegenerative Diseases _xmetabolism.
650		2	_aNeurons _xmetabolism.
650		2	_aNeurons _xpathology.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pDrug discovery and development in the neurosciences.
856	4	0	_uhttps://hstalks.com/bs/2729/
856	4	2	_uhttps://hstalks.com/bs/p/684/ _3Series
999			_c77099 _d77099