| 000 | 02613ngm a2200373 a 4500 | ||
|---|---|---|---|
| 001 | HST3541 | ||
| 003 | UkLoHST | ||
| 006 | m c | ||
| 007 | cr|cna|||a|||| | ||
| 007 | vz|czazum | ||
| 008 | 140422s2014 enk|||||||||||s|||v|eng d | ||
| 028 | 5 | 0 |
_a3541 _bHenry Stewart Talks |
| 035 | _a(UkLoHST)2772 | ||
| 040 |
_aUkLoHST _beng _cUkLoHST |
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| 100 | 1 |
_aPeters-Golden, Marc, _u(University of Michigan Medical School, USA) _4spk |
|
| 245 | 1 | 0 |
_aInfluence of eicosanoid lipid mediators on macrophage innate immune functions _h[electronic resource] / _cMarc Peters-Golden. |
| 260 |
_aLondon : _bHenry Stewart Talks, _c2014. |
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| 300 |
_a1 online resource (1 streaming video file (60 min.) : _bcolor, sound). |
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| 490 | 1 |
_aMacrophage heterogeneity and function : role in innate and adaptive immunity, _x2056-452X |
|
| 500 | _aAnimated audio-visual presentation with synchronized narration. | ||
| 500 | _aTitle from title frames. | ||
| 505 | 0 | _aContents: Mediator paradigms in innate immunity -- Eicosanoids -- Eicosanoids in antimicrobial immunity: Yin and Yang -- The leukotriene synthetic pathway -- Role of LTB4 in bacterial killing by AMs -- Pathway for NFκB activation upon PRR ligation -- Cross-talk between PRR and GPCR pathways? -- Dectin-1 -- LTB4 enhances yeast binding via dectin-1 -- Basal dectin-1 expression depends on constitutive LTB4 generation -- LTB4 enhances dectin-1-induced cytokine generation by elicited MΦ -- Dectin-1 expression in MΦ depends on an LTB4-PU.1 axis -- Pathway for NFκB activation upon TLR ligation -- LPS-induced nuclear translocation of NFκB subunits requires endogenous LTB4/BLT1 signaling -- 5-LO metabolism is required for MyD88-dependent NFkB activity in macrophages -- 5-LO and LTB4 are required for basal MyD88 expression in macrophages -- MyD88 expression is controlled by STAT-1 and SOCS1 -- SOCS1 siRNA restores MyD88 expression and LPS responsiveness in 5-LO -/- MΦs -- PGE2 actions are context-dependent -- PGE2 synthesis and signaling -- Opposing actions of PGE2 vs. LTB4 -- Eicosanoid imbalance in states of immunosuppression. | |
| 506 | _aAccess restricted to subscribers. | ||
| 538 | _aMode of access: World Wide Web. | ||
| 650 | 0 | _aEicosanoids. | |
| 650 | 0 | _aMacrophages. | |
| 650 | 0 | _aNatural immunity. | |
| 650 | 2 |
_aEicosanoids _xmetabolism. |
|
| 650 | 2 |
_aImmunity, Innate _ximmunology. |
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| 650 | 2 | _aMacrophages. | |
| 830 | 0 |
_aHenry Stewart talks. _pBiomedical & life sciences collection. _pMacrophage heterogeneity and function. |
|
| 856 | 4 | 0 | _uhttps://hstalks.com/bs/2772/ |
| 856 | 4 | 2 |
_uhttps://hstalks.com/bs/p/668/ _3Series |
| 999 |
_c77087 _d77087 |
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