000			02268ngm a2200457 a 4500
001			HST3807
003			UkLoHST
006			m c
007			cr|cna|||a||||
007			vz|czazum
008			141027s2014 enk|||||||||||s|||v|eng d
028	5	0	_a3807 _bHenry Stewart Talks
035			_a(UkLoHST)2892
040			_aUkLoHST _beng _cUkLoHST
100	1		_aBiffi, Alessandra, _u(Telethon Institute for Gene Therapy, Italy) _4spk
245	1	0	_aHematopoietic stem cell gene therapy for the treatment of metachromatic leukodystrophy _h[electronic resource] / _cAlessandra Biffi.
260			_aLondon : _bHenry Stewart Talks, _c2014.
300			_a1 online resource (1 streaming video file (37 min.) : _bcolor, sound).
490	1		_aGene transfer and gene therapy, _x2056-452X
500			_aAnimated audio-visual presentation with synchronized narration.
500			_aTitle from title frames.
505	0		_aContents: Metachromatic Leukodystrophy (MLD) -- Hematopoietic stem cell therapy (HCT) for lysosomal storage disorders (LSDs) -- Improving HCT efficacy -- The role of brain pre-conditioning -- Mechanisms of microglia turnover -- Gene therapy (GT) & enzyme release -- Gene therapy in murine models -- HSC gene therapy for MLD -- Lentivirus integration site analysis -- Stem cells analysis -- ARSA activity and delivery to the CNS -- Cerebral and peripheral demyelination -- Motor function testing (GMFM).
506			_aAccess restricted to subscribers.
538			_aMode of access: World Wide Web.
650		0	_aBrain _xDiseases _xGenetic aspects.
650		0	_aGene therapy.
650		0	_aMedical genetics.
650		0	_aStem cells _xTherapeutic use.
650		2	_aGenetic Therapy.
650		2	_aGenetics, Medical.
650		2	_aHematopoietic Stem Cell Transplantation.
650		2	_aHematopoietic Stem Cells _xmetabolism.
650		2	_aLentivirus.
650		2	_aLeukodystrophy, Metachromatic _xgenetics.
650		2	_aLeukodystrophy, Metachromatic _xtherapy.
650		2	_aMicroglia.
650		2	_aVirus Integration _xgenetics.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pGene transfer and gene therapy.
856	4	0	_uhttps://hstalks.com/bs/2892/
856	4	2	_uhttps://hstalks.com/bs/p/808/ _3Series
999			_c77001 _d77001