000			02504ngm a2200469 a 4500
001			HST3840
003			UkLoHST
006			m c
007			cr|cna|||a||||
007			vz|czazum
008			141027s2014 enk|||||||||||s|||v|eng d
028	5	0	_a3840 _bHenry Stewart Talks
035			_a(UkLoHST)2910
040			_aUkLoHST _beng _cUkLoHST
100	1		_aGoldberg, Alfred, _u(Harvard Medical School, USA) _4spk
245	1	0	_aProtein degradation and defense against neurodegenerative disease _h[electronic resource] : _bpart 2 of 2 / _cAlfred Goldberg.
246	3		_aProtein degradation and defense against neurodegenerative disease part 2 of 2
260			_aLondon : _bHenry Stewart Talks, _c2014.
300			_a1 online resource (1 streaming video file (42 min.) : _bcolor, sound).
490	1		_aProtein homeostasis : folding proteins and maintaining the protein-protein interaction networks, _x2056-452X
500			_aAnimated audio-visual presentation with synchronized narration.
500			_aTitle from title frames.
505	0		_aContents: The 26S proteasome -- The 20S proteasome -- Proteasome inhibitors -- PS-341 -- Proteasome inhibitors in multiple myeloma -- Structures of the archaeal PAN ATPase-20S complex and the eukaryotic 26S proteasome -- Multiple ATP-dependent steps in proteasome function -- The gating mechanism of the proteasome -- Prions inhibit proteasome function -- Binding of ubiquitin conjugates activate the 26S proteasome by stimulating 20S gate-opening and ATP hydrolysis -- Ubiquitin conjugates activate their own degradation by the 26S Proteasome -- The inhibitor of proteasome-associated deubiquitinating enzyme Usp14, IU1, enhances degradation of tau.
506			_aAccess restricted to subscribers.
538			_aMode of access: World Wide Web.
650		0	_aBrain _xAging _xMolecular aspects.
650		0	_aNervous system _xDegeneration.
650		0	_aProtein folding.
650		0	_aProteins _xMetabolism.
650		0	_aUbiquitin.
650		2	_aNeurodegenerative Diseases _xmetabolism.
650		2	_aProteasome Endopeptidase Complex.
650		2	_aProteasome Inhibitors.
650		2	_aProtein Folding.
650		2	_aProteins _xchemistry.
650		2	_aProteins _xmetabolism.
650		2	_aProteolysis.
650		2	_aUbiquitin _xmetabolism.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection. _pProtein homeostasis.
856	4	0	_uhttps://hstalks.com/bs/2910/
856	4	2	_uhttps://hstalks.com/bs/p/641/ _3Series
999			_c76989 _d76989