000			01940cgm a2200397 a 4500
001			HST4030
003			UkLoHST
006			m c
007			cr|cna|||a||||
007			vz|czazum
008			160115s2015 enk|||||||||||s|||v|eng d
028	5	0	_a4030 _bHenry Stewart Talks
035			_a(UkLoHST)3187
040			_aUkLoHST _beng _cUkLoHST
100	1		_aZhang, Rumin, _u(Merck, USA) _4spk
245	1	0	_aQuantitative analysis of receptor allosterism and its implication for drug discovery _h[electronic resource] / _cRumin Zhang.
260			_aLondon : _bHenry Stewart Talks, _c2015.
300			_a1 online resource (1 streaming video file (57 min.) : _bcolor, sound).
490	1		_aThe biomedical & life sciences collection, _x2056-452X
500			_aAnimated audio-visual presentation with synchronized narration.
500			_aTitle from title frames.
505	0		_aContents: G protein-coupled receptors (GPCRs) -- Receptor agonism and allosterism -- Orthosteric and allosteric binders -- Inverse, partial and full agonists -- Positive, silent and negative allosteric modulators (PAMs, SAMs and NAMs) -- Allosteric two-state model and general operational model with constitutive receptor activity -- Optimal design of experiment -- Global curve fitting analysis of affinity and efficacy parameters -- Beta supremacy -- Monte Carlo simulations.
506			_aAccess restricted to subscribers.
538			_aMode of access: World Wide Web.
650		0	_aCell receptors.
650		0	_aDrug development.
650		0	_aDrug receptors.
650		0	_aPharmaceutical chemistry.
650		2	_aDrug Agonism.
650		2	_aDrug Discovery.
650		2	_aReceptors, Cytoplasmic and Nuclear.
650		2	_aReceptors, G-Protein-Coupled _xagonists.
650		2	_aReceptors, G-Protein-Coupled _xchemistry.
830		0	_aHenry Stewart talks. _pBiomedical & life sciences collection.
856	4	0	_uhttps://hstalks.com/bs/3187/
999			_c76781 _d76781