000			06127cam a2200649Mu 4500
001			9781003056256
003			FlBoTFG
005			20220531132456.0
006			m o d
007			cr cnu---unuuu
008			201031s2020 xx o ||| 0 eng d
040			_aOCoLC-P _beng _cOCoLC-P
020			_a9781000091861
020			_a1000091864
020			_a9781003056256 _q(electronic bk.)
020			_a1003056253 _q(electronic bk.)
020			_a9781000091922 _q(electronic bk. : Mobipocket)
020			_a1000091929 _q(electronic bk. : Mobipocket)
020			_a9781000091984 _q(electronic bk. : EPUB)
020			_a1000091988 _q(electronic bk. : EPUB)
020			_z9814877301
020			_z9789814877305
024	7		_a10.1201/9781003056256. _2doi
035			_a(OCoLC)1202451998 _z(OCoLC)1202305746 _z(OCoLC)1202470352 _z(OCoLC)1202601784 _z(OCoLC)1232849428
035			_a(OCoLC-P)1202451998
050		4	_aQC318.E57
072		7	_aSCI _x013050 _2bisacsh
072		7	_aSCI _x050000 _2bisacsh
072		7	_aSCI _x055000 _2bisacsh
072		7	_aPHS _2bicssc
082	0	4	_a536.7 _223
100	1		_aStarikov, Evgeni.
245	1	0	_aEntropy-Enthalpy Compensation _h[electronic resource] : _bFinding a Methodological Common Denominator Through Probability, Statistics, and Physics.
260			_aMilton : _bJenny Stanford Publishing, _c2020.
300			_a1 online resource (419 p.)
336			_atext _2rdacontent
337			_acomputer _2rdamedia
338			_aonline resource _2rdacarrier
500			_aDescription based upon print version of record.
520			_aProfessionals recognize entropy-enthalpy compensation as an important factor in molecular recognition, lead design, water networks, and protein engineering. It can be experimentally studied by proper combinations of diverse spectroscopic approaches with isothermal titration calorimetry and is clearly related to molecular dynamics. So, how should we treat entropy-enthalpy compensation? Is it a stubborn hindrance that solely complicates the predictability of phenomena otherwise laid on the line by Mother Nature? How should we then deal with it? This book dwells on these posers. It combines two chapters written by globally recognized specialists. Chapter 1 deals with general issues and suggests a definite approach to how we may answer the posers. Chapter 2 shows how the approach outlined might be successfully applied in a rational design of enzymes. This might provide other interesting strategic perspectives in the general theoretical physical chemistry field.
505	0		_aCover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Contents -- Preface -- 1. Entropy-Enthalpy Compensation and Exploratory Factor Analysis of Correlations: Are There Common Points? -- 1.1 Introduction -- 1.2 Results and Discussion -- 1.2.1 Macroscopic Thermodynamics Considered from the Standpoint of van der Waals Equation of State -- 1.2.2 Correctness of Our Macroscopic-Thermodynamic Approach -- 1.2.3 What Is the Actual Difference between Gibbs and Helmholtz Functions? -- 1.2.4 The Actual Physical Sense of the EEC -- 1.2.5 Statistical-Mechanical Standpoint
505	8		_a1.2.6 What Is the Actual Probability Distribution behind the Statistical Mechanics? -- 1.2.7 Bayesian Statistical Thermodynamics of Real Gases -- 1.2.8 Applicability of Linhart's Approach to Real Gases -- 1.2.9 Is There Some Physical Connection between Boltzmann's and Gibbs' Entropy Formulae? -- 1.2.10 Can Our Approach Be Really Productive? -- 1.2.11 A Methodological Perspective -- 1.2.12 What Is the Actual Zest of Our Approach? -- 1.3 Conclusions -- 1.4 Outlook -- Appendix 1 to Chapter -- Appendix 2 to Chapter 1: Methodological Roots and Significance of Energetics -- A2.1 Introduction
505	8		_aA2.2 Energetics Is a Generally Applicable Concept -- A2.2.1 Foreword -- A2.2.2 The First Definition of Entropy -- A2.2.3 Introduction and Preliminary Concepts -- A2.2.4 Succinct Presentation of Thermodynamic Principles -- A2.2.4.1 Joule-Mayer principle -- A2.2.4.2 Principle of Carnot-Clausius -- A2.2.5 Energy and the Forms of Sensitivity -- A2.2.6 Third Part -- A2.2.6.1 The muscle system and energetics -- A2.2.6.2 Analogy between the muscle system and the nervous system -- A2.2.6.3 Energetics and the nervous system -- A2.2.6.4 Energetics and the nervous system (Continued)
505	8		_aA2.2.7 Thermodynamic Design of Some Mental Situations -- A2.2.8 Summary and Conclusions -- A2.3 Our General Conclusion -- A2.3.1 The Balance of Bodies: Types of Body Balance -- A2.3.2 Our Immediate Comment -- A2.4 How to Employ the Ideas of Energetics: A Methodological Reiteration -- A2.4.1 How to Make a Mechanical Theory of Mental Phenomena -- A2.4.2 -- A2.4.3 -- A2.4.4 -- A2.4.5 The Senses: Theory of the Consecutive Images -- A2.4.6 Demential Law by Paul Janet -- A2.4.7 Psychoses -- A2.4.8 Mechanical Representation of Psychic Phenomena -- A2.4.8.1 Mechanism of dementia
505	8		_aA2.4.8.2 Mechanism of sensations -- A2.4.8.3 Mechanism of psychoses -- A2.4.8.4 Consequences -- A2.4.8.5 Influence of the cerebral inertia coefficient -- A2.4.9 Conclusion -- Appendix 3 to Chapter 1: A Methodological Outlook -- 2. Polynomial Exploratory Factor Analysis on Molecular Dynamics Trajectory of the Ras-GAP System: A Possible Theoretical Approach to Enzyme Engineering -- 2.1 Introduction -- 2.2 Results and Discussion -- 2.2.1 Linear Exploratory Factor Analysis Results -- 2.2.2 Nonlinear Exploratory Factor Analysis Results -- 2.3 Detailed Description of the Method
588			_aOCLC-licensed vendor bibliographic record.
650		0	_aEntropy.
650		0	_aEnthalpy.
650		0	_aMolecular dynamics.
650		7	_aSCIENCE / Chemistry / Physical & Theoretical _2bisacsh
650		7	_aSCIENCE / Nanostructures _2bisacsh
650		7	_aSCIENCE / Physics _2bisacsh
700	1		_aNordén, Bengt, _d1945-
700	1		_aTanaka, Shigenori.
856	4	0	_3Taylor & Francis _uhttps://www.taylorfrancis.com/books/9781003056256
856	4	2	_3OCLC metadata license agreement _uhttp://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf
999			_c72837 _d72837