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001 9780429059872
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040 _aOCoLC-P
_beng
_erda
_epn
_cOCoLC-P
020 _a9780429059872
_q(electronic bk.)
020 _a0429059876
_q(electronic bk.)
020 _a9780429593482
_q(electronic bk. : Mobipocket)
020 _a0429593481
_q(electronic bk. : Mobipocket)
020 _a9780429596063
_q(electronic bk. : PDF)
020 _a0429596065
_q(electronic bk. : PDF)
020 _a9780429594779
_q(electronic bk. : EPUB)
020 _a0429594771
_q(electronic bk. : EPUB)
020 _z9781138064928
020 _z1138064920
035 _a(OCoLC)1088892375
035 _a(OCoLC-P)1088892375
050 4 _aRM151
_b.B76 2019eb
072 7 _aMED
_x071000
_2bisacsh
072 7 _aMED
_x017000
_2bisacsh
072 7 _aMED
_x072000
_2bisacsh
072 7 _aTDCW
_2bicssc
082 0 4 _a615/.6
_223
100 1 _aBrown, Marc D.,
_eauthor.
245 1 4 _aThe art and science of dermal formulation development /
_cMarc Brown, Adrian C. Williams.
264 1 _aBoca Raton, Florida :
_bCRC Press,
_c[2019]
300 _a1 online resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 0 _aDrugs and the pharmaceutical sciences
505 0 _aCover; Half Title; Series Page; Title Page; Copyright Page; Dedication; Contents; Preface; Acknowledgements; About the Authors; Chapter 1: Structure and Function of Human Skin; 1.1 Introduction; 1.2 Healthy Skin Structure and Function; 1.2.1 The Subcutaneous Fat Layer; 1.2.2 The Dermis; 1.2.2.1 Pilosebaceous Unit; 1.2.2.2 Eccrine (Sweat) Glands; 1.2.2.3 Apocrine Glands; 1.2.3 The Epidermis; 1.2.3.1 Basement Membrane; 1.2.3.2 The Stratum Basale (Stratum Germinativum or, More Commonly, Basal Layer); 1.2.3.3 The Stratum Spinosum (Spinous Layer/Prickle Cell Layer)
505 8 _a1.2.3.4 The Stratum Granulosum (Granular Layer)1.2.3.5 The Stratum Lucidum; 1.2.3.6 The Stratum Corneum (Horny Layer); 1.2.4 Epidermal Enzyme Systems; 1.3 Physiological Factors Affecting Transdermal and Topical Drug Delivery; 1.3.1 Gender; 1.3.2 Skin Age; 1.3.3 Body Site; 1.3.4 Race; 1.3.5 Other Factors; 1.4 Skin Microbiome; 1.5 Damaged Skin; References; Chapter 2: Theoretical Aspects of Transdermal and Topical Drug Delivery; 2.1 Terminology; 2.2 The Transdermal Permeation Process; 2.3 Permeation Pathways through the Stratum Corneum; 2.3.1 Transappendageal Transport (Shunt Route Transport)
505 8 _a2.3.2 Transcellular Route2.3.3 Intercellular Pathway; 2.4 Influence of Permeant Physicochemical Properties on Route of Absorption; 2.4.1 Partition Coefficient; 2.4.2 Molecular Size; 2.4.3 Solubility/Melting Point; 2.4.4 Ionisation; 2.4.5 Other Factors; 2.4.6 Biomacromolecules; 2.5 Mathematics of Skin Permeation; 2.5.1 Pseudo Steady-State Permeation (Infinite Dosing); 2.5.2 Concentration Gradient or Thermodynamic Activity?; 2.5.3 Transient Permeation (Finite Dosing); References; Chapter 3: Chemical Modulation of Topical and Transdermal Permeation; 3.1 Introduction
505 8 _a3.2 Chemical Modulation of Drug Flux3.2.1 Mechanisms of Chemical Penetration Enhancement; 3.2.1.1 Interaction (Disordering) of Intercellular Lipids; 3.2.1.2 Interactions within Corneocytes; 3.2.1.3 Alteration of Partitioning; 3.2.1.4 Other Mechanisms of Chemical Penetration Enhancement; 3.2.2 Common Chemical Penetration Enhancers; 3.2.2.1 Water; 3.2.2.2 Sulphoxides and Similar Chemicals; 3.2.2.3 Pyrrolidones; 3.2.2.4 Azone; 3.2.2.5 Fatty Acids; 3.2.2.6 Alcohols, Fatty Alcohols, and Glycols; 3.2.2.7 Surfactants; 3.2.2.8 Urea; 3.2.2.9 Terpenes; 3.2.2.10 Phospholipids
505 8 _a3.2.2.11 Amino Acid-Based Enhancers3.2.2.12 Peptides; 3.2.3 Synergy between Chemical Penetration Enhancers; 3.2.4 General Comments on Penetration Enhancers; 3.3 Permeation Retardation; 3.4 Drug and Formulation Manipulation Strategies; 3.4.1 Prodrugs; 3.4.2 Ion-Pairing; 3.4.3 Eutectic Systems/Depression of Permeant Melting Point; 3.4.4 Supersaturation; References; Chapter 4: Physical and Technological Modulation of Topical and Transdermal Drug Delivery; 4.1 Introduction; 4.2 Vesicles; 4.2.1 Liposomes; 4.2.2 Non-Ionic Surfactant Vesicles (Niosomes)
520 _aThe Art and Science of Dermal Formulation Development is a comprehensive guide to the theory and practice of transdermal and topical formulation development, covering preclinical studies, evaluation, and regulatory approval. It enables the reader to understand the opportunities and challenges in developing products and how risks can be mitigated. Over the last 25 years, expertise in this area has declined whilst drug delivery systems for other administration routes have developed significantly. The advantages offered by transdermal and topical drug delivery remain compelling for sectors including the pharmaceutical industry, personal care, and cosmetics. This text addresses the dearth of expertise and discusses how skin can be a route of delivery and the processes in formulation development, but how such an application is very different to that used for oral, IV, and other administration routes.
588 _aOCLC-licensed vendor bibliographic record.
650 0 _aTransdermal medication.
650 0 _aTransdermal medication
_xResearch
_xMethodology.
650 0 _aDermatologic agents
_xAbsorption and adsorption.
650 0 _aSkin
_xPhysiology.
650 7 _aMEDICAL / Pharmacology
_2bisacsh
650 7 _aMEDICAL / Dermatology
_2bisacsh
650 7 _aMEDICAL / Pharmacy
_2bisacsh
700 1 _aWilliams, A. C.
_q(Adrian C.)
856 4 0 _3Taylor & Francis
_uhttps://www.taylorfrancis.com/books/9780429059872
856 4 2 _3OCLC metadata license agreement
_uhttp://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf
999 _c72400
_d72400