000			06360nam a2200565Ii 4500
001			9781351261760
003			FlBoTFG
005			20220531132347.0
006			m o d
007			cr
008			181112t20182019fluab ob 001 0 eng d
020			_a9781351261760 _q(e-book : PDF)
035			_a(OCLC)1051141585
040			_aFlBoTFG _cFlBoTFG _erda
041	1		_aeng
072		7	_aMED _x008000 _2bisacsh
072		7	_aSCI _x017000 _2bisacsh
072		7	_aSCI _x049000 _2bisacsh
072		7	_aPSB _2bicscc
245	0	0	_aGlutathione / _cedited by Leopold Flohe.
250			_aFirst edition.
264		1	_aBoca Raton, FL : _bCRC Press, _c[2018].
264		4	_c©2019.
300			_a1 online resource (410 pages) : _b82 illustrations, text file, PDF.
336			_atext _2rdacontent
337			_acomputer _2rdamedia
338			_aonline resource _2rdacarrier
490	1		_aOxidative Stress and Disease
504			_aIncludes bibliographical references and index.
505	0	0	_tContents -- _tSeries Preface.......................................................xi -- _tEditors Preface.................................................... xiii -- _tEditor Biography...................................................xix -- _tList of Contributors .................................................xxi -- _t--Part I Biosynthesis, Compartmentation, -- _tand Transport of Glutathione -- _tChapter 1 --Biosynthesis of Glutathione and Its Regulation..................3 -- --Henry J. Forman, Hongqiao Zhang, and Terrance J. Kavanagh -- _tChapter 2 --Renal Glutathione Transport Systems: Roles in Redox -- _tHomeostasis, Cytoprotection, and Bioactivation................ 35 -- --Lawrence H. Lash -- _tPart II Glutathione-Dependent -- _tHydroperoxide Metabolism -- _tChapter 3 --The Catalytic Mechanism of Glutathione Peroxidases............ 53 -- --Laura Orian, Giorgio Cozza, Matilde Maiorino, Stefano -- _tToppo, and Fulvio Ursini -- _tChapter 4 --GPx1-Dependent Regulatory Processes in Health and Disease..... 67 -- --Diane E. Handy and Joseph Loscalzo -- _tChapter 5 --Glutathione Peroxidase 1 as a Modulator of Insulin Production -- _tand Signaling: Implications for Its Dual Role in Diabetes......... 81 -- --Holger Steinbrenner and Lars-Oliver Klotz -- _tChapter 6 --GPx2 Role in Physiology and Carcinogenesis..................95 -- --Anna P. Kipp -- _tChapter 7 --GPx4: From Prevention of Lipid Peroxidation to -- _tSpermatogenesis and Back................................ 111 -- --Matilde Maiorino, Antonella Roveri, and Fulvio Ursini -- _tChapter 8 --Thiols, Glutathione, GPx4, and Lipid Metabolism at the -- _tCrossroads of Cell Death and Survival....................... 129 -- --Jos Pedro Friedmann Angeli, Valerian E. Kagan, and Marcus -- _tConrad -- _tChapter 9 --Peroxiredoxin 6 as Glutathione Peroxidase................... 143 -- --Yefim Manevich -- _tChapter 10 --Glutathione Peroxidases and the Thyroid Gland............... 161 -- --Lutz Schomburg -- _tPart III Conjugations and Isomerizations -- _tChapter 11 --Glutathione Transferases: From the Test Tube to the Cell........ 175 -- --Bengt Mannervik and Birgitta Sjdin -- _tChapter 12 --Protein S-Glutathionylation and Glutathione S-Transferase P..... 201 -- --Kenneth D. Tew -- _tChapter 13 --The Role of Glutathione in Biosynthetic Pathways and -- _tRegulation of the Eicosanoid Metabolism.................... 215 -- --Ralf Morgenstern, Leopold Floh, Jesper Z. Haeggstrm, and -- _tPer-Johan Jakobsson -- _tChapter 14 --Nitric Oxide and S-Nitrosoglutathione.......................227 -- --Iain L. O. Buxton and Scott D. Barnett -- _tPart IV The Glutaredoxins -- _tChapter 15 --The Catalytic Mechanism of Glutaredoxins................... 251 -- --Linda Liedgens and Marcel Deponte -- _tChapter 16 --The Role of Glutaredoxins in the Brain......................263 -- --Carsten Berndt, Anna Dorothee Engelke, Klaudia Lepka, and -- _tLars Brutigam -- _tPart V Glutathione Derivatives and -- _tSubstitutes in Pathogenic Microorganisms -- _tChapter 17 --Biosynthesis of PolyamineGlutathione Derivatives in -- --Enterobacteria and Kinetoplastida..........................285 -- --Marcelo A. Comini -- _tChapter 18 --Trypanothione Functions in Kinetoplastida...................307 -- --Martn Hugo, Madia Trujillo, Luca Piacenza, and Rafael Radi -- _tChapter 19 --Mycothiol, a Low-Molecular-Weight Thiol Drafted for -- _tOxidative Stress Defense Duty............................. 331 -- --Leonardo Astolfi Rosado, Brandn Pedre, and Joris Messens -- _tChapter 20 --Biosynthesis and Functions of Bacillithiol in Firmicutes......... 357 -- --Quach Ngoc Tung, Nico Linzner, Vu Van Loi, -- _tand Haike Antelmann -- _tIndex--............................................................ 379.
520	3		_aThis is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-S-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets.
530			_aAlso available in print format.
650		7	_aSCIENCE / Life Sciences / Cytology. _2bisacsh
650		7	_aSCIENCE / Life Sciences / Biology / Molecular Biology. _2bisacsh
650		7	_aAdaptive Stress Response. _2bisacsh
650		7	_aBiosynthesis. _2bisacsh
650		7	_aDetoxification. _2bisacsh
650		7	_aDrug Discovery. _2bisacsh
650		7	_aRedox Reactions. _2bisacsh
650		0	_aGlutathione _vCongresses.
650		0	_aGlutathione _xMetabolism _vCongresses.
650		0	_aGlutathione.
650		0	_aGlutathione _xMetabolism.
655		0	_aElectronic books.
700	1		_aFlohe, Leopold, _eeditor.
710	2		_aTaylor and Francis.
776	0	8	_iPrint version: _z9780815365327
830		0	_aOxidative Stress and Disease.
856	4	0	_uhttps://www.taylorfrancis.com/books/9781351261760 _zClick here to view.
999			_c71282 _d71282