TUM Library

Cover; Half Title; Endorsements; Title Page; Copyright Page; Dedication; Contents; Preface; Editor; Contributors; Chapter 1: Biology of Intestinal Coccidia; 1.1 Introduction and Brief History; 1.2 Genus Eimeria (syn. Coccidium); 1.2.1 Life Cycle of Eimeria; 1.2.1.1 Oocyst; 1.2.1.2 Infection of the Host; 1.2.1.3 Asexual Development; 1.2.1.4 Sexual Development; 1.2.1.5 Extraintestinal Coccidia; 1.2.1.6 Description of Eimeria Species; 1.3 Genus Cystoisospora; 1.4 Ultrastructure; 1.4.1 Eimeria Species; 1.4.1.1 Oocysts, Sporocysts, Sporozoites; 1.4.1.2 Schizonts and Merozoites

1.4.1.3 Microgamonts and Macrogamonts1.4.2 Cystoisospora; 1.5 In Vitro Cultivation; 1.6 Pathogenesis and Lesions of Intestinal Coccidiosis; 1.7 Diagnosis; 1.8 Control; References; Chapter 2: Phylogeny of Coccidian Parasites; 2.1 Introduction; 2.2 Limits of Morphology or Phenotype in Diagnosing Related Parasite Taxa; 2.3 Molecular Markers Used in Phylogenetics; 2.4 How We Know What We Know, and the Extent of What Remains Unexplored; 2.5 Origins of Eimeria; 2.6 Lessons Learned from the Most-Studied Parasites of Livestock, and Possible Consequences of Such Investigator Bias

2.7 How Much More Has Yet to Be Discovered?References; Chapter 3: Host Immunity in Coccidiosis; 3.1 Introduction; 3.2 Immunity in Chickens; 3.2.1 Innate Immunity in Chickens; 3.2.2 Adaptive Immunity in Chickens; 3.3 Immunity against Coccidia in Other Species; 3.3.1 Turkeys; 3.3.2 Ruminants; 3.3.3 Rabbits; 3.3.4 Horses; References; Chapter 4: Vaccination; 4.1 Introduction; 4.2 Basis for Development of Live Eimeria Oocyst Vaccines; 4.3 Eimeria Developmental Stages That Induce and Are Targeted by Protective Immunity; 4.4 Virulent Vaccines; 4.5 Attenuated Vaccines

4.6 Using Vaccines in Conjunction with Anticoccidial Drugs4.7 Using Live Eimeria Oocyst Vaccines to Reduce Drug Resistance in Eimeria Population; 4.8 Genetic Diversity Impacting Efficacy of Vaccination; 4.9 Delivery of Live Vaccines; 4.10 Conclusions; References; Chapter 5: Genomics, Transcriptomics, and Proteomics of the Eimeria Species; 5.1 Introduction; 5.2 Eimeria Genomes; 5.3 Cyclospora Cayetanensis; 5.4 Eimeria Transcriptomes; 5.5 Eimeria Proteomes; 5.6 Molecular Studies of Genetic Diversity; References; Chapter 6: Anticoccidial Drugs of Livestock and Poultry Industries

6.1 Introduction6.2 Drug Categories; 6.2.1 Polyether Antibiotics or Ionophores; 6.2.2 Synthetic Compounds; 6.3 Control of Coccidiosis in Poultry; 6.3.1 Ionophores; 6.3.1.1 Monovalent Ionophores; 6.3.1.2 Monovalent Glycosidic Ionophores; 6.3.1.3 Divalent Ionophores; 6.3.2 Synthetic Compounds; 6.3.2.1 Inhibition of Parasite Mitochondrial Respiration; 6.3.2.2 Inhibition of the Folic Acid Pathway; 6.3.2.3 Competitive Inhibition of Thiamine Uptake; 6.3.2.4 Other Modes of Action; 6.3.2.5 Unknown Modes of Action; 6.3.3 Markets and Market Products; 6.3.3.1 European Union; 6.3.3.2 United States

6.3.3.3 Australia

Coccidiosis is one of the most important diseases of livestock, particularly poultry, with billions of dollars spent on prevention worldwide. The disease is so important and pervasive that until recently, all poultry feed was medicated with coccidiostats, mainly antibiotics. With the rapid development of drug resistance, the search is on for alternative methods of control of coccidiosis in poultry. With chapters authored by internationally renowned scientists, this book covers coccidiosis in all major livestock species, including cattle, sheep, and goats. Special emphasis is given to poultry coccidiosis given the significant economic impact, and another chapter looks at intestinal coccidiosis in humans, including Cyclospora. Chapters discuss techniques, molecular biology, host-pathogen immunobiology and immunoprophylaxis, genetics and genomics, biology, and chemotherapy. Despite an explosion of research in the last 40 years, there has been no new book published discussing conventional coccidiosis for more than 25 years. This comprehensive review therefore answers an urgent need for a book dealing exclusively with conventional coccidia (Cystoisospora, Cyclospora). It provides concise, authoritative, up-to-date information on coccidiosis, with particular attention given to research in the last 28 years. This book is essential reading for any practitioner or researcher involved in livestock production, including biologists, veterinarians, parasitologists, and researchers from government, academia, and industry.

OCLC-licensed vendor bibliographic record.