The Beta-globin locus [electronic resource] / Ann Dean.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer: ; Henry Stewart talksBiomedical & life sciences collection. Eukaryotic gene regulation : from chromatin to transcription to mRNA processing: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (35 min.) : color, sound)Other title: β-globin locusSubject(s): Epigenesis | Genetic regulation | Genetic transcription -- Regulation | Hemoglobin | Sickle cell anemia | Anemia, Sickle Cell -- genetics | beta-Globins -- genetics | beta-Thalassemia -- genetics | Cell Nucleus -- metabolism | Chromatin -- genetics | Chromosome Structures | Epigenesis, Genetic | Erythroid Cells -- metabolism | Eukaryotic Cells | Gene Expression Regulation | Genetic Loci | Hemoglobin Subunits | Hemoglobins | Transcription Factors -- physiology | Transcription, GeneticOnline resources: Click here to access online | Series (Eukaryotic gene regulation) | Series (Epigenetics, chromatin, transcription and cancer) Animated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2007.
Contents: The globin loci encode hemoglobin subunits -- Erythrocytes & hemoglobin -- Human globin genes and hemoglobins -- Globin gene expression during development -- Globin gene structure -- Sickle cell disease -- Beta-thalassemia -- Transcriptional regulation by recruitment (Enhancers, Silencers and Insulators) -- Chromatin conformation capture (3C) assay -- Chromatin looping in the beta-globin locus -- The LDB1 complex in erythroid cells -- Nuclear re-location of the beta-globin locus -- Natural mutations and hemoglobin switching -- BCL11A, beta-globin and gamma-globin expression -- Interfering with BCL11A silencing.
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Mode of access: World Wide Web.