Purines in Parkinson's [electronic resource] : from epidemiology of caffeine and urate to therapeutics / Michael Schwarzschild.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Parkinson's disease: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (62 min.) : color, sound)Subject(s): Caffeine -- Health aspects | Parkinson's disease -- Epidemiology | Parkinson's disease -- Treatment | Purines | Caffeine -- therapeutic use | Central Nervous System Stimulants -- therapeutic use | Parkinson Disease -- epidemiology | Parkinson Disease -- therapy | Purines -- metabolism | Uric Acid -- therapeutic useOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Purines in Parkinson's: from epidemiology of caffeine and urate to therapeutics -- Purines as PD protectants -- Purines & Parkinson's -- Pursuing Epi clues to protection for Parkinson's -- Coffee, tea and the risk of PD -- Caffeine consumption and a reduced risk of PD: Possible explanations for this inverse association -- Caffeine, post-menopausal estrogen and risk of Parkinson's disease -- Caffeine targets in humans -- CSC reverses MPTP neurotoxicity -- Adenosine A2A receptor KO mimics caffeine's protective effect in the MPTP model of PD -- Potential benefits of A2AR blockade in PD -- Caffeine and A2A receptors in models of PD -- Brain distribution of adenosine receptors -- Brain distribution of adenosine receptors -- Industry A2A antagonists advancing to clinical trials for PD -- Caffeine consumption & the risk of dyskinesia in PD -- Urate oxidase mutations during primate evolution -- Advantage of higher urate? -- Epidemiology of urate and PD -- Serum urate predicts progression of Parkinson's disease -- higher urate predicts a slower rate of PD progression -- Functional imaging can identify dopaminergic deficits of PD -- Higher serum urate at baseline predicts a slower rate of losing DA transporter binding sites in PD -- CSF and serum urate as predictors of progression of Parkinson's disease -- Is urate a predictor of slower progression in other neurodegenerative diseases? -- Urate prevents dopaminergic neuron death in primary cultures of midbrain neurons -- Astrocytes potentiate the neuroprotective effects of inosine and urate -- Urate prevents MPP+-induced dopaminergic neuron degeneration -- SURE-PD study -- UpUrS-PD study.
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Mode of access: World Wide Web.