Genetic basis of neurological disease [electronic resource] / Nicholas Wood.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Genetic basis of neurological disorders: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (34 min.) : color, sound)Subject(s): Nervous system -- Degeneration -- Genetic aspects | Nervous system -- Diseases -- Genetic aspects | Parkinson's disease -- Genetic aspects | Genome-Wide Association Study | Nervous System Diseases -- genetics | Neurodegenerative Diseases -- genetics | Parkinson Disease -- genetics | Sequence Analysis, DNA -- trendsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Neurogenetics -- Allele frequency vs. effect size -- Parkinson's disease (PD) -- PINK1: genetic discovery to protein expression -- Pink1 and mitochondrial abnormalities -- In vivo interaction between PINK1 and Parkin -- Parkinsonian proteins and mitophagy -- Mitochondrial dysfunction -- Protein aggregation -- Ceramide metabolism and PD -- Lysosomal pathway and PD -- Complex trait genetics -- Linkage disequilibrium blocks -- Identifying common genetic factors -- Genetic risk factors & odds of finding variants -- First genome-wide association study for PD -- Parkinson's disease molecular pathways -- Replicate meta-analysis -- The major neurological diseases -- Caveats to consider in GWAS -- The ENCODE study -- Trinucleotide repeats and related disorders -- The impact of next generation sequencing.
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Mode of access: World Wide Web.