GPCRs and pain [electronic resource] / Christoph Stein.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. G Protein-Coupled Receptors (GPCRs) signaling in health and disease: Publisher: London : Henry Stewart Talks, 2019Description: 1 online resource (1 streaming video file (36 min.) : color, sound)Subject(s): Analgesia | Cellular signal transduction | G proteins -- Receptors | Opioids -- Therapeutic use | Pain | Analgesics, Opioid | Computer Simulation | Ligands | Nociception | Nociceptive Pain | Pain -- drug therapy | Receptors, G-Protein-Coupled | Receptors, Opioid | Signal TransductionOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Anatomical & physiological principles underlying nociception & pain -- Examples of GPCR mediating excitatory & inhibitory effects on pain sensation -- Cross-talk between excitatory & inhibitory intracellular signalling pathways (GPCR in sensory neurons) -- Adverse side effects mediated by opioid receptors in the nervous system -- Selective activation of peripheral opioid receptors on sensory neurons in injured tissues -- Computational simulation of dynamic opioid receptor-ligand interactions (normal vs. injured) -- Novel opioid ligand (NFEPP): analgesia in models of inflammatory pain without adverse side effects.
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Mode of access: World Wide Web.