Global analysis of gene translation [electronic resource] / Philip Tofilon.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Microarrays : their design and use: Publisher: London : Henry Stewart Talks, 2009Description: 1 online resource (1 streaming video file (38 min.) : color, sound)Subject(s): Gene Expression | Microarray Analysis | Oligonucleotide Array Sequence Analysis | Protein Biosynthesis -- radiation effectsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Radiation-induced gene expression has long been considered to play a role in determining cellular radioresponse -- Analyses of single genes and whole genomes indicate that radiation-induced changes at the mRNA level do not correlate with changes in corresponding proteins -- Microarray analysis of polysome-bound RNA indicates that radiation modifies the translational activity of mRNA subpopulations, which correlates with protein products -- Gene translation is considerably more susceptible to radiation-induced changes than is the transcriptome -- Defining the genes whose translation is modified by radiation may provide an approach for identifying critical proteins and pathways that serve as determinants of radiosensitivity.
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Mode of access: World Wide Web.