Small interfering RNA induced transcriptional gene silencing in human cells [electronic resource] / Kevin V. Morris.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. RNA interference : principles and applications: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (29 min.) : color, sound)Subject(s): Cells | Gene Silencing | RNA Interference | RNA, Small Interfering | Transcription, GeneticOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: How siRNAs mediate transcriptional gene silencing (TGS) in human cells -- Histone methylation -- Dependency on active RNA polymerase II mediated transcription -- siRNA-mediated TGS -- H3K9 and H3K27 methylation of the targeted EF1A promoter -- Nuclear specific delivery of the siRNA -- Antisense strand-specific siRNA-mediated TGS of EF1A -- Targeting of the U3 region of the HIV-1 LTR/promoter -- Antisense strand of siRNA EF2 interacts with FLAG-tagged DNMT3A and the tri-methylated H3K27 methyl mark -- siRNA mediated targeting of genomic regions -- RNA Pol-II function -- Transcriptional gene silencing in human cells.
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Mode of access: World Wide Web.