New designs for siRNAs as Dicer-substrates [electronic resource] / Mark Behlke.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. RNA interference : principles and applications: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (43 min.) : color, sound)Other title: New designs for small interfering RNAs as Dicer-substratesSubject(s): RNA Interference | RNA, Small InterferingOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Potency of RNA duplexes of ~27 nucleotides in length -- Dicer substrates -- Variation in dicing patterns -- Defined substrate preferences for Dicer -- Design of RNA duplexes that are processed to specific, desired products -- Dicer processing introduces functional asymmetry into the potency of a RNA duplex -- Preferential binding of Dicer to 3'-overhand -- The exploitation of Dicer properties to improve design of RNAi reagents.
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Mode of access: World Wide Web.