Nonsense-mediated and Staufen1-mediated mRNA decay [electronic resource] : related pathways of post-transcriptional control in mammalian cells / Lynne E. Maquat.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. From DNA to proteins : the multiple levels of regulation: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (40 min.) : color, sound)Other title: Nonsense-mediated and Staufen1-mediated messenger RNA decay : related pathways of post-transcriptional control in mammalian cells | RNA surveillanceSubject(s): Cellular control mechanisms | Genetic regulation | Messenger RNA | RNA stability | Cytoskeletal Proteins -- physiology | Eukaryotic Initiation Factors -- metabolism | Exons | Nonsense Mediated mRNA Decay | Protein Isoforms | RNA Cap-Binding Proteins | RNA Processing, Post-Transcriptional | RNA Splicing | RNA Stability | RNA, Double-Stranded | RNA, Messenger | RNA-Binding ProteinsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Three core Upf NMD factors -- Exon junction complexes (EJCs) -- Upf1 -- Mechanism of NMD -- Activation of EJC-bound Upf1 -- Role of NMD in downregulating spliced mRNAs to eliminate truncated proteins -- NMD downregulating functional protein isoforms -- Restriction to newly synthesized mRNAs during a pioneer round of translation -- Cap Binding Protein (CBP) heterodimer CBP80-CBP20 -- Eukaryotic translation initiation factor (eIF) 4E and steady state mRNA -- Role of CBP80 in enhancing efficiency of NMD by promoting the interaction of Upf1 with EJC-bound Upf2 -- Staufen (Stau)1-mediated mRNA decay (SMD) -- Double-stranded RNA binding protein Stau1 -- Mechanism of action of SMD.
Access restricted to subscribers.
Mode of access: World Wide Web.