The interaction of antibiotics with the large ribosomal subunit from Haloarcula Marismortui [electronic resource] / Peter Moore.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Mechanisms of ribosome function : insights into protein synthesis: Publisher: London : Henry Stewart Talks, 2008Description: 1 online resource (1 streaming video file (49 min.) : color, sound)Subject(s): Haloarcula Marismortui -- drug effects | Protein Biosynthesis | Ribosomal Proteins | RibosomesOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Introduction to a paradox: how can a universally conserved cellular component be a target for pharmacologically useful antibiotics? -- Introduction to ribosome structure -- Antibiotic binding sites cluster in the ribosome -- The source of the species specificity of antibiotics that interact with the A-site cleft -- How macrolides interact with the ribosome -- The structural consequences of mutations that make ribosomes resistant to macrolides -- The toxicity of macrolides is not well understood -- 13-deoxytedanolide, a novel macrolide with novel species specificity that binds to a novel site in the ribosome.
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Mode of access: World Wide Web.