Titin 127 [electronic resource] : a protein with a complex folding landscape / Jane Clarke.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Protein folding, aggregation and design : concepts, experiments, theories and mechanisms: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (38 min.) : color, sound)Subject(s): Muscle Proteins | Protein Conformation | Protein Folding | Protein Kinases | ProteinsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Examination of the folding of titin 127 -- Evolution of the protein to withstand stress from mutation, the environment and to withstand mechanical force in the muscle -- Use of a combination of protein engineering, kinetic and thermodynamic measurements, computer simulations and single molecule atomic force microscopy to understand how evolution acts on protein sequences to allow them to adapt to stressful conditions, probably explaining why immunoglobulin-like proteins are used so successfully in evolution to perform a number of functions.
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Mode of access: World Wide Web.