Pleiotropic and epistatic genes in sickle cell anemia [electronic resource] / Ronald L. Nagel.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Protein epidemiology: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (39 min.) : color, sound)Subject(s): Protein Conformation | ProteinsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
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Contents: Determination of pleiotropic genes -- Search for polymorphic genes among the pleiotropic genes as candidates for epistasis -- Known epistatic effects -- Kidney pathology in sickle cell disease -- Renal disease epidemiology -- Panoply of transgenic mice -- Involvement of metabolic pathways in constitutive chronic kidney damage in Tx mice -- Hypoxia -- Mediators of oxidative stress -- Up and down regulated genes -- HO- 1 histopathology -- The effect of sickle red blood cell adhesion on gene expression in PAF pre-treated microcirculatory bed -- Von Willebrand factor (vWF) and sickle cell anemia -- vWF, shear stress and sickle cell anaemia -- Epistatic genes may open new therapeutic strategies for SS disease -- PAF induces the up-regulation of a number of genes that have the capacity of protecting the endothelium, stem cells and other hematopoetic precursors.
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Mode of access: World Wide Web.