Novel proteins from designed combinatorial libraries [electronic resource] / Michael H. Hecht.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Protein folding, aggregation and design : concepts, experiments, theories and mechanisms: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (49 min.) : color, sound)Subject(s): Protein Conformation | Protein Engineering | Protein Folding | ProteinsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Novel proteins can be devised using either rational/computational approaches or random/combinatorial methods -- Description of a hybrid approach that combines rational and combinatorial methods: libraries of novel proteins -- Combinatorial diversity -- Random vs. focused libraries -- Amphiphilic alpha-helices and beta-strands -- Binary patterning of polar and non-polar amino acids -- Genetic encoding of combinatorial mixtures of polar and non-polar amino acids -- Design of libraries of novel 4-helix bundles -- Library construction and expression in vivo -- Dynamic vs. wellordered protein structures -- Second generation libraries -- Biophysical characterization -- Solution structure of native-like 4-helix bundle proteins from designed libraries -- Functionally active proteins including cofactor binding proteins, peroxidases and esterases -- Designed libraries of beta sheet proteins: amyloid-like fibrils, monomeric beta-sheet proteins and novel biomaterials.
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Mode of access: World Wide Web.