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RNAi and heterochromatin in plants and fission yeast [electronic resource] / Robert Martienssen.

By: Martienssen, Robert A [spk]Material type: FilmFilmSeries: Henry Stewart talksBiomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms: ; Henry Stewart talksBiomedical & life sciences collection. RNA interference : principles and applications: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (41 min.) : color, sound)Subject(s): Epigenesis, Genetic | Heterochromatin | Plants | RNA Interference | SchizosaccharomycesOnline resources: Click here to access online | Series (Epigenetics) | Series (RNA interference)
Contents:
Contents: Heterochromatin is composed of transposable elements (TEs) and related repeats -- heterochromatic gene silencing and TE-mediated silencing are related and may be important in large genomes -- tiling microarrays can be used to examine heterochromatic transcripts as well as DNA and histone modification -- small interfering RNA (siRNA) corresponds to transposons and repeats -- in plants TE siRNA depend on DNA methyltransferase MET1 and the SWI/SNF ATPase DDM1 which silence TEs via DNA and histone H3 lysine-9 (H3K9) methylation -- in fission yeast and plants centromeric repeats are transcribed on one strand but rapidly turned over by RNA interference (RNAi) -- RNAi of centromeric transcripts is required for transcriptional silencing of reporter genes -- RNA polymerase II, the Argonaute (RITS) and RNA dependent RNA polymerase (RDRC) complexes are associated with heterochromatin and required for silencing -- H3K9me2 depends on RNAi and on the Rik1-Clr4 complex -- Clr4 is the histone H3K9 dimethyltransferase -- Rik1 resembles both DNA and RNA binding proteins and is required for RNAi along with Clr4 -- LTR retrotransposon silencing depends on histone deacetylation and silences pericentromeric repeats in Arabidopsis in addition to RNAi.
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Animated audio-visual presentation with synchronized narration.

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Contents: Heterochromatin is composed of transposable elements (TEs) and related repeats -- heterochromatic gene silencing and TE-mediated silencing are related and may be important in large genomes -- tiling microarrays can be used to examine heterochromatic transcripts as well as DNA and histone modification -- small interfering RNA (siRNA) corresponds to transposons and repeats -- in plants TE siRNA depend on DNA methyltransferase MET1 and the SWI/SNF ATPase DDM1 which silence TEs via DNA and histone H3 lysine-9 (H3K9) methylation -- in fission yeast and plants centromeric repeats are transcribed on one strand but rapidly turned over by RNA interference (RNAi) -- RNAi of centromeric transcripts is required for transcriptional silencing of reporter genes -- RNA polymerase II, the Argonaute (RITS) and RNA dependent RNA polymerase (RDRC) complexes are associated with heterochromatin and required for silencing -- H3K9me2 depends on RNAi and on the Rik1-Clr4 complex -- Clr4 is the histone H3K9 dimethyltransferase -- Rik1 resembles both DNA and RNA binding proteins and is required for RNAi along with Clr4 -- LTR retrotransposon silencing depends on histone deacetylation and silences pericentromeric repeats in Arabidopsis in addition to RNAi.

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