LKB1 pathway and its role in cancer [electronic resource] / Dario Alessi.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Protein phosphorylation: Publisher: London : Henry Stewart Talks, 2011Description: 1 online resource (1 streaming video file (63 min.) : color, sound)Subject(s): Neoplasms | Phosphorylation | Protein KinasesOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Mutations in LKB1 kinase cause Peutz Jeghers cancer syndrome -- LKB1-activation and effects -- LKB1/AMPK signaling pathway inhibits mTOR -- Evaluating the role of LKB1 in regulating PTEN-induced tumourigenesis -- AMPK-activators-mechanisms of action -- AMPK-activators delay tumor onset in mice -- Metformin as a useful drug in cancer prevention -- The LKB1:STRAD:MO25 complex -- Potential evolution of a pseudokinase -- LKB activation by STRAD and MO25 -- Location of LKB1 cancer mutations -- Activating protein kinases as a key challenge -- Analysis of the NUAK protein kinase -- Studying the role LKB1/NUAK1 signaling pathway in regulating cell adhesiveness and migration -- Modeling the novel LKB1.
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Mode of access: World Wide Web.