TUM Library

Animated audio-visual presentation with synchronized narration.

Title from title frames.

Updated version of a talk first published in 2007.

Contents: Nitric oxide reaction with superoxide radical: the formation of peroxynitrite -- Peroxynitrite-mediated thiol oxidation -- Peroxynitrite decomposition pathways: one vs two-electron oxidation processes -- Thyl radicals and sulfenic acids -- Peroxynitrite kinetics and stopped flow analysis -- Peroxynitrite reaction with fact reaction thiols, the case of peroxiredoxins -- Peroxynitrite reaction with transition metals -- The reaction of peroxynitrite with carbon dioxide: the formation of carbonate radicals -- Proton-catalyzed homolysis of peroxynitrite to hydroxyl radicals -- Lipid peroxidation and nitration -- Protein tyrosine nitration, a free radical process -- Protein tyrosine nitration in disease states -- Peroxynitrite and mitochondrial dysfunction -- Role of peroxynitrite in pathology -- Peroxynitrite therapeutics.

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