Oxidatively generated damage to DNA [electronic resource] : mechanistic aspects and formation in cells / Jean Cadet.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Free radicals and the oxygen paradox : oxidative stress in biology, aging and disease: Publisher: London : Henry Stewart Talks, 2020Description: 1 online resource (1 streaming video file (49 min.) : color, sound)Subject(s): DNA damage | Oxidative stress -- Pathophysiology | DNA Damage | DNA -- radiation effects | Enzyme Assays | Epigenesis, Genetic | Hydroxyl Radical | Oxidants | Oxidation-Reduction | Oxidative Stress | Radiation, Ionizing | Singlet OxygenOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2007.
Contents: Oxidative stress and cellular oxidants -- Nucleobase degradation pathways induced by hydroxyl radical, singlet oxygen and one-electron oxidants -- Oxidatively generated damage to cellular DNA: single and tandem lesions -- Epigenetic marks: enzymatic oxidation of 5-methycytosine -- Measurement of oxidized bases: chromatographic and enzymatic assays -- Base oxidation products formed in cellular DNA upon exposure to ionizing radiations and UVA component of solar light.
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Mode of access: World Wide Web.