The molecular biology of Huntington's disease [electronic resource] / David Rubinsztein.
Material type: FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Neurodegenerative diseases : fundamentals, research methods, latest advances: Publisher: London : Henry Stewart Talks, 2020Description: 1 online resource (1 streaming video file (46 min.) : color, sound)Subject(s): Huntington's disease | HTT protein, human | Huntingtin Protein | Huntington Disease -- genetics | Huntington Disease -- pathology | Huntington Disease -- therapy | Molecular Biology | Neurodegenerative Diseases | Protein Aggregates | Reactive Oxygen Species | RNA, Small Interfering | Trinucleotide Repeat ExpansionOnline resources: Click here to access online | SeriesAnimated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2007.
Contents: Clinical presentations of HD -- Pathological features -- Genetic basis -- Trinucleotide repeat expansion mutation -- Huntingtin protein and cell damage -- Abnormal protein aggregation -- Transcriptional abnormalities -- Raised levels of reactive oxygen species -- Future directions for therapeutic intervention -- siRNA approaches -- Induction of autophagy.
Access restricted to subscribers.
Mode of access: World Wide Web.