Protein degradation [electronic resource] / Alfred L. Goldberg.
Material type: FilmSeries: Henry Stewart talksBiomedical & life sciences collection. From DNA to proteins : the multiple levels of regulation: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (55 min.) : color, sound)Subject(s): Proteins -- Metabolism | Proteolysis | Ubiquitin | Adenosine Triphosphate | Antigen Presentation | Cell Cycle | Gene Expression Regulation | I-kappa B Proteins | Lysosomes | NF-kappa B | Proteasome Endopeptidase Complex | Proteasome Inhibitors | Proteins -- metabolism | Proteolysis | Signal Transduction | Ubiquitin-Protein Ligase ComplexesOnline resources: Click here to access online | SeriesAnimated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.
Access restricted to subscribers.
Mode of access: World Wide Web.