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Cover -- Half Title -- Series Page -- Title Page -- Copyright Page -- Contents -- Preface -- 1 Intelligent Nanomaterials for Medicine: Carrier Platforms and Targeting Strategies-State of the Art -- 1.1 Introduction -- 1.2 Nanotechnology Carrier Platforms Suited for Switch Functionality -- 1.2.1 Micelles and Liposomes -- 1.2.2 Polymeric Systems -- 1.2.3 Dendrimers -- 1.2.4 Carbon Nanotubes -- 1.2.5 Metallic Nanoparticles -- 1.2.6 Other Organic Nanoparticles: Carbohydrate-Based NPs, e.g., Chitosan and Starch -- 1.2.7 Quantum Dots and Carbon Quantum Dots -- 1.2.8 Nanogels

1.2.9 Peptide-Based Nanoparticles as Delivery System -- 1.3 Advanced Functionality Including Internal and External Stimuli-Responsiveness -- 1.4 Engineering Cell and Tissue Interaction at the Nanoscale -- 1.4.1 Targeting Strategies -- 1.4.1.1 Passive targeting -- 1.4.1.2 Active targeting -- 1.4.2 Endocytotic Cellular Uptake -- 1.4.3 Cellular Uptake by Cell-Penetrating Peptides -- 1.4.4 Endosomal Escape -- 1.4.5 Exocytosis -- 1.5 Clinical Application of Nanomaterials -- 1.5.1 The Clinical Trial Landscape: An Emphasis on Cancer

1.5.2 Potential Risk Factors Regarding Approved Nanoparticle-Based Therapies -- 1.6 Conclusions and Outlook -- 2 Nanocarriers as an Emerging Platform for Cancer Therapy -- 2.1 Passive and Active Targeting -- 2.2 Types of Targeting Agents -- 2.3 The Arsenal of Nanocarriers -- 2.4 The Challenges of Multidrug Resistance -- 2.5 Into the Future -- 3 Microfluidic Technologies for Accelerating the Clinical Translation of Nanoparticles -- 3.1 Well-Controlled Synthesis of Nanoparticles -- 3.2 Evaluation and Screening of Nanoparticles -- 3.3 Future Prospects -- 4 Theranostic Nanomedicine

4.1 Introduction -- 4.2 Imaging Drug Delivery -- 4.3 Imaging Drug Release -- 4.4 Imaging Drug Efficacy -- 4.5 Conclusions -- 5 The Emerging Field of RNA Nanotechnology -- 5.1 Significance and Uniqueness of RNA Nanotechnology -- 5.2 Distinct Attributes of RNA inside the Body -- 5.3 Techniques for Constructing RNA Nanoparticles -- 5.4 Applications of RNA Nanotechnology -- 5.5 Challenges and Perspectives -- 6 Drug Targeting to Tumors: Principles, Pitfalls and (Pre-) Clinical Progress -- 6.1 Introduction -- 6.2 Principles of Drug Targeting to Tumors -- 6.2.1 Passive Targeting

6.2.2 Active Targeting to Cancer Cells -- 6.2.3 Active Targeting to Endothelial Cells -- 6.2.4 Triggered Drug Delivery -- 6.3 Pitfalls in Drug Targeting to Tumors -- 6.3.1 Extravasation and the EPR Effect -- 6.3.2 Penetration -- 6.3.3 Active Targeting -- 6.3.4 Formulation -- 6.3.5 Efficacy vs. Toxicity -- 6.3.6 Metastasis -- 6.3.7 Personalization -- 6.3.8 Translation -- 6.4 (Pre-) Clinical Progress -- 6.5 Conclusion -- 7 Biomolecular Coronas Provide the Biological Identity of Nanosized Materials -- 7.1 Nanoscale Engagement with Biological Processes

This book is the second in a series presenting articles that received the most citations in recent years in nanomedicine. The series is edited by, a prominent nanotechnology researcher and editor-in-chief of Precision Nanomedicine. The theme of the second volume is about nano-enabled medical applications. The 19 articles collected here have already acquired more than 12,500 citations highlighting the importance and professional recognition of the work of these scientists in nanomedicine. The content includes the general overview of the field and a wide variety of applications that have been impossible without nanoscience and nanotechnology.

OCLC-licensed vendor bibliographic record.