WNK1 pathway and its role in regulating hypertension [electronic resource] / Dario Alessi.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Protein phosphorylation: Publisher: London : Henry Stewart Talks, 2011Description: 1 online resource (1 streaming video file (51 min.) : color, sound)Subject(s): Hypertension | Phosphorylation | Protein KinasesOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Mutations in WNK kinases cause familial hypertension -- WNK1 interacts with and activates SPAK and OSR1 -- Physiological functions of SPAK and OSR1 -- Hyperosmotic conditions affect NKCC1 via WNK1 and SPAK/OSR1 -- A suggested mechanism of action for Thiazide diuretics in Gordon's syndrome patients -- How the WNK pathway regulates blood pressure-a current model -- Defining physiological roles of SPAK in knock-in mice -- MO25 also regulates the activity of SPAK/OSR1 -- Functions and schematic representation of LKB1 and SPAK/OSR1 protein complexes.
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Mode of access: World Wide Web.