Enhancer malfunction in cancer [electronic resource] / Ali Shilatifard.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (41 min.) : color, sound)Subject(s): Cancer cells | Chromatin | Genetic regulation | Leukemia -- Genetic aspects | Cell Transformation, Neoplastic | Chromatin -- genetics | Gene Expression Regulation | Histone-Lysine N-Methyltransferase | Leukemia -- genetics | Myeloid-Lymphoid Leukemia Protein | Neoplasms -- genetics | Transcriptional Elongation Factors -- metabolismOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: MLL genes and their pathogenic translocations -- Yeast, mammalian and Drosophila systems for studying leukaemia pathogenesis -- Proteins and protein complexes that regulate chromatin modifications, transcription initiation, and transcription elongation -- What is the function of MLL? -- Why do translocations of MLL with so many different partners result in leukemogenesis? -- The AFF4 complex and Hox genes -- COMPASS family of H3K4 methylases and their mutations in cancer -- Chromatin Bivalency -- The ELL family of Pol II elongation factors -- Drosophila Trr -- Enhancer/promoter interactions, malfunctions and their outcomes.
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Mode of access: World Wide Web.