The role of myeloid cells in HIV associated immune reconstitution inflammatory syndrome [electronic resource] / Robert Wilkinson and Graeme Meintjes.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Cells of the innate immune system: Publisher: London : Henry Stewart Talks, 2012Description: 1 online resource (1 streaming video file (28 min.) : color, sound)Subject(s): HIV Infections | Immunologic diseases | HIV Infections -- immunology | Immune Reconstitution Inflammatory Syndrome -- pathology | Myeloid Cells | Tuberculosis -- immunologyOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: TB-immune reconstitution inflammatory syndrome (IRIS) is a common complication of combined antitubercular and antiretroviral therapy -- The two forms of IRIS: paradoxical and unmasking -- Lack of a diagnostic test for TB-IRIS -- Expansion of Interferon gamma secreting T cells is associated with TB-IRIS -- Multiple cytokines are elevated in TB-IRIS, many of myeloid origin -- Benefits of adjunctive corticosteroid therapy in TB-IRIS -- Steroid therapy reduces the levels of IL-6, IL-10, IL-12p40, TNF, Interferon-gamma and CXCL-10 in TB-IRIS patients -- Suppurative necrosis may occur in TB-IRIS, implying a role for neutrophils -- Evidence of a prominent role for myeloid cells in the pathogenesis of TB-IRIS.
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Mode of access: World Wide Web.