Protein networks and analysis of global gene expression [electronic resource] / Trey Ideker.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. From DNA to proteins : the multiple levels of regulation: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (47 min.) : color, sound)Subject(s): Bioinformatics | Computational biology | Genetic regulatory networks | Protein protein interactions | Proteomics | Systems biology | Computational Biology -- trends | Databases, Protein | Fungal Proteins -- metabolism | Gene Expression Regulation -- physiology | Gene Expression Regulation, Fungal -- physiology | Gene Regulatory Networks -- physiology | Genomics -- methods | Models, Genetic | Protein Interaction Maps -- genetics | Proteins -- metabolism | Proteomics -- methods | Saccharomyces cerevisiae -- genetics | Systems Biology -- trendsOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: A paradigm shift: from databases of protein sequences to protein interactions -- Technologies for measuring interactions -- Chromatin immunoprecipitation (ChIP) -- Yeast Two Hybrid (Y2H) technology -- Mass spectrometry based approaches -- Methods for querying protein networks with gene expression profiles -- Systematic validation of protein network models using gene deletions -- Cytoscape open-source software for network modeling and visualization -- Methods for network comparison across species -- Application to discover conserved protein complexes among the networks of yeast, worm, fly and Plasmodium -- Methods for querying protein networks to explain genetic (synthetic lethal) interactions -- Future directions: how network queries will enable systems biology.
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Mode of access: World Wide Web.