Tracking vector insertion sites to explore the biology of transduced cells in vivo [electronic resource] / Christof Von Kalle.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Gene transfer and gene therapy: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (35 min.) : color, sound)Subject(s): Gene therapy | Genetic transformation | Genetic vectors | Lentiviruses | Medical genetics | Genetic Therapy -- methods | Genetic Vectors -- genetics | Hematopoietic System | Lentivirus -- genetics | Severe Combined Immunodeficiency | Virus Integration -- genetics | Wiskott-Aldrich Syndrome -- therapy | X-Linked Combined Immunodeficiency DiseasesOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Clonal marking by integrating vectors -- Integration site analysis by LAM-PCR -- Analysis of gene therapy clinical trials for X-SCID, X-CGD, ADA-SCID & Cancer -- Avoiding oncogenesis in gene therapy -- Gene therapy for Wiskott-Aldrich Syndrome (WAS) -- Characterization & understanding of pathogenesis -- Integrations in known proto-oncogenes -- Possible triggers of AML development -- Safer vector systems & new technologies -- Lentiviral SIN-vectors -- Influence of vector type on clinical outcome -- LV integration site analysis: X-ALD trial -- Repopulation of hematopoietic system -- Targeted genome modification: nucleases -- Specificity of DNA modification by ZFN -- The TALEN nuclease and how it performs.
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Mode of access: World Wide Web.