Nuclear organization and gene expression [electronic resource] / David L. Spector.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms: ; Henry Stewart talksBiomedical & life sciences collection. From DNA to proteins : the multiple levels of regulation: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (40 min.) : color, sound)Other title: Nuclear organisation and gene expressionSubject(s): Cell Nucleus | DNA | Epigenesis, Genetic | Gene Expression Regulation | Gene Expression | Proteins | Transcription FactorsOnline resources: Click here to access online | Series (Epigenetics) | Series (From DNA to proteins) Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Current understanding of the organization of the mammalian cell nucleus and how this organization impacts on gene expression -- in-vivo studies of gene expression as a result of the concerted processes of transcription, mRNA processing, messenger ribonucleoprotein particle (mRNP) export and translation -- studies of spatial and temporal aspects of critical cellular processes within the context of the living cell -- development of a cell system that allows the visualization of a transcription site and its mRNA and protein products directly in living cells -- evaluation of spatial and temporal changes in chromatin structure, mRNA synthesis and factor association/disassociation during the transition from a transcriptionally inactive to an active state -- understanding of the in-vivo dynamics of gene expression will provide the basis from which to elucidate spatial and/or temporal alterations that occur in cells associated with various disease states.
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Mode of access: World Wide Web.