Development of antibody prodrug conjugates activated by legumain [electronic resource] / Hans-Georg Lerchen.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection: Publisher: London : Henry Stewart Talks, 2021Description: 1 online resource (1 streaming video file (35 min.) : color, sound)Subject(s): Antibody-drug conjugates | Drug development | Antibodies, Monoclonal | Antineoplastic Agents | asparaginylendopeptidase | Cysteine Endopeptidases | Immunoconjugates | Prodrugs | TWEAK ReceptorOnline resources: Click here to access online Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Modular composition of antibody drug conjugates -- ADC mode of action -- TWEAK receptor as an ADC target -- Improvements to achieve stable antibody conjugation -- KSP inhibitors as ADC toxophores -- Legumain-cleavable antibody prodrug conjugates -- Conceptualization of Antibody Prodrug Conjugates (APDCs) to increase the therapeutic window.
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Mode of access: World Wide Web.