Polyadenylation of mRNA precursors [electronic resource] : mechanism, regulation and connections with other cellular processes / James L. Manley.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. From DNA to proteins : the multiple levels of regulation: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (47 min.) : color, sound)Subject(s): Gene expression | Genetic regulation | Messenger RNA | Polyadenylation | BARD1 protein, human | Cleavage Stimulation Factor | DNA Damage | Endonucleases | Gene Expression Regulation | Oocytes | Polyadenylation | RNA Polymerase II | RNA Precursors | RNA, Messenger | Transcription Factors | Transcription, Genetic | UbiquitinationOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Polyadenylation of mRNA precursors -- The polyadenylation machinery -- A surprising complexity in PAP -- Hyperphosphorylation by MPF inhibits PAP activity -- Gld-2 in cytoplasmic polyadenylation in oocytes -- The polyadenylation machinery -- CPSF-73 is the 3' processing endonuclease -- CPSF-73 is absent in cytoplasmic polyadenylation -- CstF protein interactions -- Regulation of gene expression by alternative polyadenylation -- The C-terminal domain of RNAPII -- The CTD can stimulate 3' cleavage in vitro -- CPSF links transcription and 3' end formation -- RNA15 crosslinks to promoters -- Polyadenylation and links to other cellular processes -- CstF-50 -- BRCA1 -- BARD1 -- BRCA associated ring domain protein -- Why does BARD1 inhibit 3' processing? -- DNA damage inhibits 3' processing -- How does BARD1 inhibit 3' processing? -- BRCA1/BARD1 target RNAPII for ubiquitination -- Many factors constitute the mRNA 3' end formation machinery.
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Mode of access: World Wide Web.