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Mismatch repair deficient cancers diagnosis, treatment and prevention [electronic resource] / John Burn.

By: Burn, John [spk]Material type: FilmFilmSeries: Henry Stewart talksBiomedical & life sciences collection. Molecular genetics of human disease: Publisher: London : Henry Stewart Talks, 2014Description: 1 online resource (1 streaming video file (44 min.) : color, sound)Subject(s): Aspirin | Cancer -- Genetic aspects | Colon (Anatomy) -- Cancer -- Genetic aspects | Colon (Anatomy) -- Cancer -- Treatment | Medical genetics | Molecular genetics | Rectum -- Cancer -- Genetic aspects | Rectum -- Cancer -- Treatment | Aspirin -- therapeutic use | Biomarkers | Colorectal Neoplasms -- diagnosis | Colorectal Neoplasms -- genetics | Colorectal Neoplasms -- therapy | Colorectal Neoplasms, Hereditary Nonpolyposis | DNA Mismatch Repair | Genetics, Medical | Microsatellite Instability | Microsatellite RepeatsOnline resources: Click here to access online | Series
Contents:
Contents: Lynch syndrome (underlying single gene defect) -- Microsatellites -- Important genes containing repeat sequences -- MSI testing (5 marker panel) -- Mismatch repair (MMR) -- The genomic pathogenesis of colorectal cancer (CRC) -- EGFR and BRAF mutant inhibition -- BRAF colon cancer project -- Methotrexate & MMR deficient tumours -- Africans & bowel cancer (Dennis Burkitt) -- Cancer prevention program (CaPP) -- NSAIDs and reduced colorectal cancer risk -- Aspirin effect on polyps in FAP and colorectal adenoma -- The prevention paradox -- CaPP2 (Colorectal & Lynch syndrome cancers) -- Meta-analysis of cancer deaths with aspirin treatment -- CRCs in people on aspirin (mostly COX2 negative) -- Individual response to aspirin in cancer prevention -- History of salicylate as an essential nutrient -- CaPP3 study -- Peptides created by slippage in microsatellite coding -- Antibodies as a possible biomarker for Lynch syndrome -- The Micoryx vaccine.
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Animated audio-visual presentation with synchronized narration.

Title from title frames.

Contents: Lynch syndrome (underlying single gene defect) -- Microsatellites -- Important genes containing repeat sequences -- MSI testing (5 marker panel) -- Mismatch repair (MMR) -- The genomic pathogenesis of colorectal cancer (CRC) -- EGFR and BRAF mutant inhibition -- BRAF colon cancer project -- Methotrexate & MMR deficient tumours -- Africans & bowel cancer (Dennis Burkitt) -- Cancer prevention program (CaPP) -- NSAIDs and reduced colorectal cancer risk -- Aspirin effect on polyps in FAP and colorectal adenoma -- The prevention paradox -- CaPP2 (Colorectal & Lynch syndrome cancers) -- Meta-analysis of cancer deaths with aspirin treatment -- CRCs in people on aspirin (mostly COX2 negative) -- Individual response to aspirin in cancer prevention -- History of salicylate as an essential nutrient -- CaPP3 study -- Peptides created by slippage in microsatellite coding -- Antibodies as a possible biomarker for Lynch syndrome -- The Micoryx vaccine.

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